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Signalchem/SGK3, Active/10 ug/S08-10G-10

Overview:

SGK3isamemberoftheSGKfamilyandencodesaphosphoproteinwithaPX(phoxhomology)domain.PKD1canphosphorylateandactivateSGK3invitro(1).A10-foldincreaseinPKD1increasesthephosphorylationstatusofSGK3.Whenexpressedinhumanembryonickidneycells,IGF1andperoxidesignificantlyactivateSGK3,andtheactivationcouldbereducedbypreincubationwithinhibitorsofPI3kinase.Ayeast2-hybridscreenfounddirectinteractionbetweenhumanSGK3andGSK3β.SGK3phosphorylatesseveraltargetproteinsandhasaroleinneutralaminoacidtransportandactivationofpotassiumandchloridechannels(2).

GeneAliases:

CISK,SGKL

GenbankNumber:

NM_013257

References:

1.Kobayashi,T.etal:Characterizationofthestructureandregulationoftwonovelisoformsofserum-andglucocorticoid-inducedproteinkinase.Biochem.J.344:189-197,1999.2.Gamper,N.etal:K+channelactivationbyallthreeisoformsofserum-andglucocorticoid-dependentproteinkinaseSGK.Europ.J.Physiol.445:60-66,2002.

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