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Stemcell/Human Recombinant Activin A/1000 u00b5g/78001.3188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Stemcell/Human Recombinant Activin A/1000 u00b5g/78001.3

Overview

Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins produced by many cell types throughout development (Gurdon et al.). It is a disulfide-linked homodimer (two beta-A chains) that binds to heteromeric complexes of a type I (Act RI-A and Act RI-B) and a type II (Act RII-A and Act RII-B) serine-threonine kinase receptor (Attisano et al.). Activins primarily signal through SMAD2/3 proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (McDowell et al.). Activin A maintains the undifferentiated state of human embryonic stem cells (James et al.; Xiao et al.) and also facilitates differentiation of human embryonic stem cells into definitive endoderm (D’Amour et al.).
Alternative Names:
Activin beta-A chain, EDF, Erythroid differentiation protein, FRP, FSH-releasing protein, INHBA, Inhibin beta-A chain, Inhibin beta-1
Cell Type:
Pluripotent Stem Cells; Other; Endoderm, PSC-Derived; Mesoderm, PSC-Derived
Species:
Human
Area of Interest:
Stem Cell Biology; Epithelial Cell Biology
Molecular Weight:
26.2 kDa
Purity:
≥ 95%
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