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| Product Name | GPR65 / TDAG8, Polyclonal Antibody | ||
| Also Known As | Rabbit Polyclonal to Human GPR65 / TDAG8 | ||
| Product Synonym Names | Anti-GPR65 / TDAG8 Antibody (Extracellular Domain) IHC-plus; GPR65; G-protein coupled receptor 65; Gpcr25; HTDAG8; TDAG8; T-cell death-associated gene 8; Psychosine receptor; G protein-coupled receptor 65; Human GPR65; TDAG8 | ||
| Product Gene Name | anti-GPR65 antibody | [Similar Products] | |
| Product Synonym Gene Name | TDAG8 | [Similar Products] | |
| Research Use Only | For Research Use Only. Not for use in diagnostic procedures. | ||
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| OMIM | 604620 | ||
| 3D Structure | ModBase 3D Structure for Q8IYL9 | ||
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| Clonality | Polyclonal | ||
| Host | Rabbit | ||
| Species Reactivity | Human | ||
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| Specificity | Human GPR65. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except VCL (50%), CPS1 (39%). | ||
| Purity/Purification | Immunoaffinity Purified | ||
| Form/Format | PBS, 0.1% sodium azide. | ||
| Concentration | 1 mg/ml (lot specific) | ||
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| Target Species | Human | ||
| Immunogen Description | Synthetic 18 amino acid peptide from 3rd extracellular domain of human GPR65. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon (94%). | ||
| Immunogen Type | Synthetic peptide | ||
| Immunogen | GPR65 / TDAG8 antibody was raised against synthetic 18 amino acid peptide from 3rd extracellular domain of human GPR65. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon (94%). | ||
| Antigen Modification | Extracellular Domain | ||
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| Preparation and Storage | Long term: -70 degree C; Short term: +4 degree C | ||
| Other Notes | Small volumes of anti-GPR65 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. | ||
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| Product Description specifically for anti-GPR65 antibody | GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. | ||
| Product Categories/Family for anti-GPR65 antibody | Family: GPCR | ||
| Applications Tested/Suitable for anti-GPR65 antibody | Immunohistochemistry (IHC - Paraffin) | ||
| Application Notes for anti-GPR65 antibody | IHC-P (10 ug/ml) | ||
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| Immunohistochemistry (IHC) of anti-GPR65 antibody | Anti-GPR65 antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. | ||
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| NCBI GI # | 33695104 | ||
| NCBI GeneID | 8477 | ||
| NCBI Accession # | NP_003599.2 | [Other Products] | |
| NCBI GenBank Nucleotide # | NM_003608.3 | [Other Products] | |
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| UniProt Primary Accession # | Q8IYL9 | [Other Products] | |
| UniProt Secondary Accession # | O75819 | [Other Products] | |
| UniProt Related Accession # | Q8IYL9 | [Other Products] | |
| Molecular Weight | 39,333 Da | ||
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| NCBI Official Full Name | psychosine receptor | ||
| NCBI Official Synonym Full Names | G protein-coupled receptor 65 | ||
| NCBI Official Symbol | GPR65 | [Similar Products] | |
| NCBI Official Synonym Symbols | TDAG8; hTDAG8 | [Similar Products] | |
| NCBI Protein Information | psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein | ||
| UniProt Protein Name | Psychosine receptor | ||
| UniProt Synonym Protein Names | G-protein coupled receptor 65; T-cell death-associated gene 8 protein | ||
| Protein Family | Psychosine receptor | ||
| UniProt Gene Name | GPR65 | [Similar Products] | |
| UniProt Synonym Gene Names | TDAG8 | [Similar Products] | |
| UniProt Entry Name | PSYR_HUMAN | ||
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| UniProt Comments for GPR65 | GPR65: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells. Belongs to the G-protein coupled receptor 1 family. | ||
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| Research Articles on GPR65 | |||
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| Precautions | All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. | ||
| Disclaimer | While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. | ||