Camptothecinisanalkaloidcompoundusedasananti-canceragent.ItisatopoisomeraseIinhibitorinDNAsynthesis.CamptothecinhasbeenshowntobindandstabilizeatopoisomeraseI-DNAcomplexinvitro,preventingtheenzymefromreannealingDNAstrands.ThisinhibitionspecificallyeffectstheS-phaseofcelldevelopmentandultimatelyresultsinapoptosisduetodamagedDNA.
Camptothecinisproducedbyendosymbioticfungi,fromthedivisionAscomycota(Phycomycete),thatarepresentinthetreeCamptothecaacuminatawhichisnativetosouthernChina.Camptothecin(Mappiafoetida),(GoldBioCatalog#C-565)hasalsobeenisolatedfromfungionMappiafoetida(Nothapodytesfoetida),aplantcommontoIndia.
ProductSpecifications
Camptothecin(Camptothecaacuminata)
Formula:C20H16N2O4
MW:348.65g/mol
Storage/Handling:Storedesiccatedat4°C.
PubChemChemicalID:24360