GoldBio/1Dodecylimidazole/D4105/5 g

1-Dodecylimidazoleisgroupedwiththeimidazoleorganiccompounds,containinganimidazole1,3-C3N2ringproducedbynaturalproductslikealkaloids.Imidazoleisamphotericandaromatic.Whenanadditionalcarbonandtwohydrogensbindtotheringofthiscompound,1-Dodecylimidazolecanproducea1-dodecyl-3-methylimidazoliumcation.

Asanantifungal,1-DodecylimidazolecaninhibitsterolC14demethylationatlowlevels,2,3-oxidosqualenecyclizationandsubsequenttransmethylationwhenthequantityisraised.Thishasbeenpostulatedasaresultofitsbindingtosterolcarrierproteins.Itfunctionsasahypocholesterolaemicagentbyinhibitingcholesterolbiosynthesisatthelevelof2,3-oxidosqualenesterolcyclase.

Thissubstancehasbeenaneffectiveantimalarialagentwithin15minutesofadministrationtoinvitroculturesofthepathogen.Itexhibitedinhibitionofproteinsynthesisandthealkalinizationoftheparasiticfoodvacuole.ThechemicalhasalsobeenobservedfunctioningasalysosomotropicdetergentagainstSaccharomycescerevisiae.

ProductSpecifications
1-Dodecylimidazole
N-Dodecylimidazole
1-dodecyl-1H-imidazole

Formula:C₁₅H₂₈N₂

MW:236.40g/mol

Storage/Handling:Storeat4°C.

PubChemChemicalID: 78002