Reaction Biology Gets NIH Grant for Epigenetic Drug Database

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July11,2014

Epigeneticdatabasesareoneofofourfavoritefuturistictoolsand nowatimetravelingcrewfrom ReactionBiologyCorporation(RBC) land agrantfromthe NationalCenterforAdvancingTranslationalSciences (NCATS) tocreateanimpressivedatabaseofepigeneticdruginteractions.TheteamatRBCisundertakingacolossaleffortexamining alibraryof1,400compounds,includingalmosteveryFDAapproveddrug.Theyplantoassaythemagainstoverthirtyepigeneticenzymes,leADIngtoatotalofover42,000individualexperiments!TheRBCteamplanstousethisepigeneticdrugdatabasetogeneratearoadmapfor thecreationof newdrugsandgiveahelpinghandintakingonvariousepigeneticdiseasesanddisorders.Interestingly,notonlywillRBCcreatenewdrugsbuttheyalsoplantousetheirdatafromthesideeffectsofknownFDAdrugstore-purposeexistingdrugsfornewtreatments.

Dr.HaichingMa,ChiefScienceOfficerofRBCandprincipalinvestigatoroftheepigeneticdrugdatabase,sharesthat“Thisprojectwillrepresentthefirstsystematiclookathowcurrentpharmaceuticalsaffectepigeneticfunction.Thepotentialexistsforsomeexcitingdevelopmentsasaresult.We’reverypleasedthatNCATSsawthesamepotentialinthisprojectaswedid.”

TheRBCteamsharesthatTestingthesecompoundsagainstallofthehistonemethyltransferases(HMTs)thatweofferforscreeningisjustthetipoftheiceberg.Eventuallywewillextendtheseeffortstootherepigeneticclasses,includingdemethylases,readerproteins,HDACs,etc.TheultimategoalistocreateadatabasethatdemonstratesallpossIBLeinteractivemapsbetweencommonlyusedchemicalsandnewepigeneticfactors.ThiswillbethefirstdatabaseavailabletoindicatetheunknownepigeneticeffectsofFDA-approveddrugsoragentsinclinicaltrials. ObtainingalistofknownHMTinhibitingstructureswouldsignificantlyaccelerateepigeneticdrugdiscovery,ultimatelyprovidinggreaterinsightstotheactivity,potentialbenefitsandsafetyofdrugsonthemarket.Inaddition,weanticipatethisdatabasewillhelpacceleratethedevelopmentofnewdrugscurrentlybeinginvestigated,andmaybeusefulindrugrescueandrepurposingefforts.

TheyalsosharethatoncecompleteThedatabasewillbepubliclyavailabletoanyoneonline,similartothekinaseprofilingdatabasewecreatedincollaborationwiththeFoxChaseCancerCenterofPhiladelphia.

BasedinMalvern,PA,RBCspecializesinprovidinghighqualitybiochemicalenzymeassaydata,usingultra-lowvolumesandproprietarymethods.RBCprovidesservicestoover550customersworldwide,includinglargepharmaceutical,biotech,government,andacademiclabs.RBCsHotSpotSMplatformisawidelyusedserviceforprovidinghighqualitykinaseandepigeneticscreeningdataworldwide.Thecompanyalsomanufacturesandsellsrecombinanthumanepigeneticproteinsforresearchservices.

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