Aik2|Aim1|AIRK2|ARK2|serine/threonine-proteinkinase12|serine/threonine-proteinkinase5|STK-1|STK12|STK5
Description:HumanAuroraBKinaseincomplexwithINCENPandVX-680(tozasertib)
Downloadallstructure-activitydataforthistargetasaCSVfile
Description:MeasuringphosphorylationofAurBsubstratehistoneH3inA549cells.
Description:Inabiochemicalhomogeneoustime-resolvedfluorescence(HTRF)kinaseassaywithanATPconcentrationof1mM.
EMDMilliporeKinaseProfilerTMscreen/ReactionBiologyKinaseHotspotSMscreen
Ascreenprofiling158kinaseinhibitors(CalbiochemProteinKinaseInhibitorLibraryIandII,cataloguenumbers539744and539745)fortheirinhibitoryactivityat1Mand10Magainst234humanrecombinantkinasesusingtheEMDMilliporeKinaseProfilerTMservice.
Ascreenprofilingtheinhibitoryactivityof178commerciallyavailablekinaseinhibitorsat0.5Magainstapanelof300recombinantproteinkinasesusingtheReactionBiologyCorporationKinaseHotspotSMplatform.
http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx
AurorakinaseB(aspartofthepassengercomplex)localisetocentromeresfromprometaphasetometaphase.Followingchromatidseparation,AurorakinaseBredistributestomidzoneandpersistsatthemidbodyuntilcytokinesisiscompleted.
AurorakinaseBisacomponentofthechromosomalpassengercomplexwhichfunctionstoensureaccuratechromosomesegregationandcellbodydivisionduringmitosis.
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Aurorakinase(Aur)family:aurorakinaseB.Lastmodifiedon04/09/2019.Accessedon18/05/2020.IUPHAR/BPSGuidetoPHARMACOLOGY,http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1937.
