西安Reaction BiologyX中国代理价格，厂家 Reaction Biology激酶

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ReactionBiology描述：

人类重组EZH2incomplexwithhumanrecombinantsEED.TotalcomplexMWis228.7kDa.Allproteinsarefull长度（residue2throughC末端）也是全美-expressedinaninsectcell/baculovirusexpressionsystem.TheEEDsubunitincorporatesanN-terminalStrepandFlag-tagandallothersincludeanN-terminalHis-tag.CatalyzesthetransferofmethylgroupsfromS腺苷-L-甲硫氨酸（SAM）tothee-aminofunctionofproteinL-lysineresidues，specificallylysine-27ofhistoneH3（H3K27）。在开发过程中，PolycombRepressiveComplex2（PRC2）是主要的甲基转移酶对IBL的反应eforgeneratingtrimethylatedhistoneH3lysine-27（的H3K27me3），anepigeneticmarkessentialforprogrammedrepressionofgeneexpression1-5.EZH2，whichincludesaSETmethyltransferasedomain，isthecatalyticsubunitofPRC21,6.ThecoreofthecatalyticcomplexincludesEZH2，EED，SUZ12andRbAp48，whileadditionofAEBP2significantlyenhancesthemethyltransferaseactivityofthecomplex（>3×）6.EZH2isoverexpressedinawiderangeofhumancancersanditsoverexpressioncancorrelatewithtumorprogression，increasedmetastasisandpoorprognosis（seereview7）.DepletionofEZH2and/orotherPRC2componentscaninhibitgrowthorinduceapoptosisincancercells6,8-10.Consequently，EZH2isconsideredapromisingtargetforthedevelopmentofanti-癌症疗法11

存取编号： EZH2NM_001203247，EEDNM_003797，SUZ12NM_015355

包括酰胺酸：EZH22-746，EED2-441，SUZ122-739

标记（S）：EEDhasanN末端链霉菌标记标签，其他所有N末端His标签

分子量：228.7kDa

EXPRESSIONSYSTEM ：昆虫细胞/杆状病毒

SUPPLIEDAS：Solutionofpurifiedrecombinantproteinin20mMTris盐酸，pH8,150mMNaCl，2mMMgCl 2，2mMDTT，20％甘油（w/v），0.01％NP-40asdeterminedbyOD 280。

储存：-70°C。在使用前应迅速融化并储存。应保留未使用的未稀释蛋白质，例如干燥/冰乙醇液中的氮。尽可能减少冻融/解冻，但不建议使用稀释体积太小（<5µl）的稀释蛋白质。

ReactionBiology公司成立于2001年，是专门从事早期药物发现化验服务的公司，提供广泛的服务，包括用于激酶和表观遗传生物化学以及基于细胞的高通量筛选（HTS）和选择性化合物分析的稳定测定技术。我们还提供相关的HTS检测试剂，包括高度纯化和特征化的表观遗传蛋白。平均每年进行数百万次HTS和性能分析。在全球有超过750家公司（包括制药，生物技术，学术和非营利实验室）购买我们的产品。

货号   产品   价格（美元）
HMT-11-376   ASH1L(His)Methyltransferase   325
DMT-21-124   DNMT1   450
DMT-21-125   DNMT3aMethyltransferase   450
DMT-21-126   DNMT3b   450
HMT-11-101   DOT1LMethyltransferase   395
HMT-25-115   EZH1Complex   450
HMT-25-114   EZH2Complex   799
HMT-25-173   EZH2-Y641FComplex   799
HMT-11-102   G9aMethyltransferase(GST)(aa786-1210)   299
HMT-11-245   G9aMethyltransferase(His)(aa913-1193)   299
HMT-12-104   G9a/GLPComplexMethyltransferase   325
HMT-11-103   GLPMethyltransferaseProtein   299
HMT-15-105   MLL1Complex   499
HMT-15-106   MLL2Complex   499
HMT-15-107   MLL3Complex   499
HMT-15-108   MLL4Complex   499
MT-11-359   NNMT(GST)(NicotinamideN-Methyltransferase)   299
MT-11-358   NNMT(His)(NicotinamideN-Methyltransferase)   299
HMT-11-319   NRMT1(GST)   325
HMT-21-139   NSD1Methyltransferase   450
HMT-21-1380   NSD2(His)Methyltransferase   450
HMT-21-122   NSD2Methyltransferase   550
HMT-11-377   NSD2SET(His)   325
HMT-21-159   NSD2-E1099KMethyltransferase   599
HMT-11-378   NSD2-E1099K-SET(His)   325
HMT-21-181   NSD2-T1150AMethyltransferase   450
HMT-11-379   NSD2-T1150A-SET(His)   325
HMT-11-132   NSD3Methyltransferase   325
HMT-21-348   PRDM2Methyltransferase   325
HMT-21-152   PRDM9Methyltransferase   450
HMT-11-119   PRMT1Methyltransferase   325
HMT-11-113   PRMT3Methyltransferase   325
HMT-11-120   PRMT4Methyltransferase   399
HMT-21-172   PRMT5Methyltransferase   450
HMT-22-434   PRMT5(C449S)/MEP50   799
HMT-22-148   PRMT5/MEP50Complex   799
HMT-11-121   PRMT6Methyltransferase(GST)   325
HMT-21-380   PRMT6Methyltransferase(His)   325
HMT-21-382   PRMT7(His)   450
HMT-11-135   PRMT8Methyltransferase   325
MT-11-356   s-COMT(His)(SolubleCatechol-O-Methyltransferase)   299
MT-11-357   s-COMT(V108M)(His)(SolubleCatechol-O-Methyltransferase）   299
HMT-15-116   SET1AComplex(5-subunits)   499
HMT-15-117   SET1BComplex(5-subunits)   499
HMT-11-133   SET7/9Methyltransferase   299
HMT-11-476   SET8(GST)   299
HMT-11-118   SET8Methyltransferase   299
HMT-11-128   SETD2(GST)Methyltransferase   299
HMT-11-129   SETD2(His)Methyltransferase   299
HMT-11-110   SMYD2Methyltransferase   325
HMT-11-111   SUV39H1Methyltransferase   299
HMT-11-418   SUV39H2(GST)Methyltransferase   299
HMT-11-112   SUV39H2(His)Methyltransferase   299
HMT-21-149   SUV420H1-tv1Methyltransferase   450
HMT-21-150   SUV420H1-tv2Methyltransferase   450
HMT-21-349   SUV420H2Methyltransferase   325
HMT-14-109   WRAD2   375
HMT-14-438   (H3.3-H4)2Tetramer   325
HMT-35-435   CoreHistones(Chicken)   250
HMT-11-184   Fibrillarin(GST)   325
HMT-11-183   Fibrillarin(His)   325
HMT-11-137   GST-GAR   299
HMT-12-316   H2A/H2Bdimers   325
HMT-11-180   HistoneH1.0   50
HMT-11-146   HistoneH2A   50
HMT-11-147   HistoneH2B   50
HMT-11-134   HistoneH3.3   50
HMT-35-179   Nucleosomes(ChickenMono/Di)   280
HMT-35-182   Nucleosomes(ChickenOligo/PolyH5Enriched)   280

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