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Abbiotec/TRIM5 alpha Antibody/253466/0.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/TRIM5 alpha Antibody/253466/0.1 mg
TRIM5isamemberofabroadfamilyofotherwiseunrelatedproteinsdefinedbythepresenceofatripartitemotifcontainingaRINGdomain,aB-boxtype1,andaB-boxtype2,followedbyacoiled-coilregion.TRIM5hassixalternatelysplicedisoforms,thelongestofwhichistheαvariantwhichalsocontainsacarboxy-terminalB30.2(SPRY)domain.ExpressionofTRIM5αvariantsfromhumans,rhesusmonkeys,andAfricangreenmonkeysenabledresistancetoinfectionbyvariousretrovirusesincludingHIV-1,albeitatdifferingefficiencies.AllTRIM5αvariantscouldinhibitatleasttwodifferentretroviruses,butnotfromthosevirusesisolatedfromthesamespecies,suggestingthatTRIM5αactsasanaturalbarriertocross-speciesretrovirustransmission.

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