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Abbiotec/IEX1 Antibody/253736/0.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/IEX1 Antibody/253736/0.1 mg
IEX-1isastressinduciblegenethatisinducedbyionizingradiation,ultravioletradiation,andavarietyofgrowthfactors,i.e.,FASandTNF-alpha.IEX-1iswidelyexpressedinepithelialandendocrinetissues,aswellasinvascularendothelium.Itplaysanimportantroleintheregulationofcellulargrowth,celldeathandoncogenesis.IEX-1ispreciselyregulatedbymultipletranscriptionfactorssuchasp53,NF-kappaB/rel,Sp1andc-Myc,toensurerapidandtransientexpressionofIEX-1incellsunderavarietyofstressconditions.IEX-1isexpressedasbothalongerform(IEX1L)andasplicevariant,designatedIEX1S.Itislocalizedtothenucleusandperinuclearregion.OverexpressionofIEX-1facilitatesapoptosisandcellcycleprogression,whereasdisruptionofIEX-1expressionisassociatedwithdecreasesinbothapoptosisandcellcycleprogression.

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