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Abbiotec/IL-32 Antibody/253602/0.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/IL-32 Antibody/253602/0.1 mg

Interleukin-32(IL-32)wasinitiallyidentifiedasatranscript(NK4)thatisselectivelyexpressedinlymphocytesandNKcellsandwhoseexpressionisincreasedfollowingactivationbyIL-2.Itwaslaterre-isolatedfromanIL-18-treatedlungcarcinomacelllineandre-namedIL-32.IL-32isunusualinthatitdoesnotsharesequencehomologywithknowncytokinefamiliesandishighlyexpressedinimmunetissues,existinginatleastfourdifferentiallysplicedisoforms.BecausetreatmentofhumanmonocyticandmousemacrophagecellswithIL-32inducesseveralproinflammatorycytokinessuchasTNF-alpha,IL-8andMIP-2,andbecauseitisalsoinducedinhumanperipherallymphocytecellsaftermitogenstimulationandinepithelialcellsbyIFNgamma,ithasbeensuggestedthatIL-32mayplayaroleinautoimmuneandinflammatorydiseasessuchasrheumatoidarthritis.
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