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Abbiotec/BMX (1C6) Antibody/253003/0.1 ml188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/BMX (1C6) Antibody/253003/0.1 ml

BMX(BonemarrowXkinase)isacytoplasmictyrosinekinaseidentifiedbyreversetranscriptionofmRNAisolatedfromhumanbonemarrowandmappedtothechromosomalbandXp22.2.Thefulllengthproteinis675aminoacidswithatyrosinekinasedomain,anaminoterminalpleckstrindomain,aswellasanSH3andSH2domain.DirectcomparisonofBMXsprimarysequencewithotherkinasesshowedthatthisishighlyrelatedtothefamilyofBTK/ITK/TEC.BMXkinaseisexpressedinfetalandadulttissues,withthehighestexpressioninheart,testis,smallintestineandcolon.Itisundetectableinspleen,brain,kidney,andpancreas.FurtheranalysisofmRNAexpressionshowedthatBMXisexpressedinhematopoietictissuesandneutrophilicgranulocytes,andinpatientswithacuteandmyeloidleukemia.ThelevelsofBMXmRNAweresubstantiallylowerinpatientswithacuteandchroniclymphoidleukemias,thussuggestingthatBMXmaybeimportantduringmyelopoiesis.Itisexpressedinavarietyofhematopoietic,epithelialandendothelialcells.

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