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Abbiotec/CCDC98 Antibody/253767/0.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/CCDC98 Antibody/253767/0.1 mg
CCDC98,alsoknownasAbraxas1,wasidentifiedthroughproteinbindingstudiesusingthebreastandovarianpredispositionproteinBRCA1asthebindingtarget.CCDC98recruitsRAP80,aubiquitin-bindingprotein,toBRCA1,allowingtheformationofBRCA1fociinresponsetoDNAdamagecausedbyionizingradiation.BothCCDC98andRAP80arerequiredforDNAdamageresistance,G2-Mcheckpointcontrol,andDNArepair.CellsdepletedofeitherCCDC98orRAP80exhibitedincreasedsensitivitytoionizingradiation,althoughnotasmuchasinBRCA1-depletedcells,suggestingthatCCDC98andRAP80controlonlypartoftheDNAdamageresponseroleofBRCA1.AtleasttwoisoformsofCCDC98areknowntoexist.

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