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Abbiotec/IRAK2 Antibody/253354/0.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/IRAK2 Antibody/253354/0.1 mg
Thepro-inflammatorycytokineIL-1inducescellularresponsethroughtwosubunitsofitsreceptor,IL-1receptorI(IL-1RI)andIL-1receptoraccessoryprotein(IL-1RAcP).IL-1receptor-associatedkinase(IRAK)mediatesactivationofNF-kappaB,whichisapivotaltranscriptionfactormediatinginflammatoryandimmuneresponse.AnovelmemberintheIRAK/PellefamilywasrecentlyidentifiedanddesignatedIRAK2.BothIRAKandIRAK2recruittothesubunitsoftheIL-1RcomplexafterIL-1bindingandleadtoNF-kappaBactivation.IRAKsalsoassociatewithToll-likereceptor(TLR)andthedominantnegativemutantsofIRAKsinhibitLPS-inducedNF-kappaBactivation.MembersinIRAK/PellefamilyplayacentralroleinIL-1RandTLRmediatedinflammatoryresponsestocytokineIL-1andLPS.IRAK2isexpressedinavarietyofhumantissues.

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