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Abbiotec/STIM1 Antibody/253719/0.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Abbiotec/STIM1 Antibody/253719/0.1 mg
InTlymphocytes,thesolepathwayforCa++entryfollowingantigen-receptorbindingisthroughstore-operatedCa++-release-activatedCa++(CRAC)channels.Thesechannelsaremadeupofthepore-formingsubunitORAI1andthestromalinteractionmolecule1(STIM1),aproteinthatfunctionsasaCa++sensorandactivatestheCRACchannels,migratingtotheplasmamembranefromendoplasmicreticulum(ER)-likesiteswhichactastheCa++store.Arelatedmolecule,STIM2,actstoinhibittheSTIM1-mediatedstore-operatedCa++entry,andcanformcomplexeswithSTIM1,suggestingtheymayplayacoordinatedroleincontrollingCa++entry.AtleasttwoisoformsofSTIM1areknowntoexist;thisantibodywilldetectonlythelargerform.ThisSTIM1antibodyispredictedtohavenocross-reactivitytoSTIM2.

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