FabGennix/hopQ H. Pylori Antibody/HOPQ101AP/

GeneralInformation

Product

hopQAntibody

Description

AffinityPurifiedhopQH.PyloriAntibody

VerifiedApplications

CM,ELISA,ICC,IF,IP,IHC,WB

Host

Rabbit

SpeciesCrossReactivity

Heliobacterpylori

Immunogen

HeatkilledanddenaturedHeliocobacterpyloriextracts

Accession#

GenBank:EJC48598.1

PhysicalProperties

Quantity

100µg

Volume

200µl

Concentration

0.80-1.35µg/µlinantibodystABIlizationbuffer

Form

AffinityPurified

Clonality

Polyclonal

Storage

-20⁰Cforlongtermstorage

ApplicationProtocol

ConfocalMicroscopy

1:200

ELISA

1:5,000

Immunocytochemistry

1:200

Immunofluorescence

1:300

Immunohistochemistry

1:200

Immunoprecipitation

1:150

WesternBlot

1:500

Protein

Uniprot#

J0TJV0

Overview

PlaysanimportantroleinthemaintenanceoftheGolgicomplex,inmembranetrafficking,inexocytosis,throughitsinteractionwithmyosinVIandRab8.LinksmyosinVItotheGolgicomplexandplaysanimportantroleinGolgiribbonformation.NegativelyregulatestheinductionofIFNBinresponsetoRNAvirusinfection.

MolecularFunction

polyubiquitinbinding,RabGTPasebinding,proteinC-terminusbinding

SubcellularLocation

Cytoplasm›perinuclearregion.Golgiapparatus.Golgiapparatus›trans-Golginetwork.Cytoplasmicvesicle›autophagosome.Cytoplasmicvesicle.Recyclingendosome

Expression

Presentinaqueoushumoroftheeye(atproteinlevel).Highlyexpressedintrabecularmeshwork.Expressednonpigmentedciliaryepithelium,retina,brain,adrenalcortex,fetus,lymphocyte,fibroblast,skeletalmuscle,heart,liver,brainandplacenta.

Structure

InteractswithHD,Rab8(RAB8Aand/orRAB8B)(activeGTP-boundform),GTF3A,TRAF3,TBK1,MYO6andTFRC.Bindstolinearubiquitinchains.InteractswithLC3familymembersMAP1LC3A,MAP1LC3B,GABARAP,GABARAPL1andGABARAPL2;OPTNphosphorylationincreas

AlternativeNomenclature

H.pyloriantibody