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GeneralInformation |
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Product |
InhibinalphaAntibodyAffinityPurified |
Description | AffinityPurifiedInhibinalphachain;FlagsAntibodyC-epitope |
VerifiedApplications | CM,ELISA,ICC,IF,IHC,WB |
Host | Rabbit |
SpeciesCrossReactivity | Human,85%homologywithmouseprotein |
Immunogen | Syntheticpeptidetakenwithinaminoacidregion220-270onhumanalphaInhibin. |
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Quantity |
100µg |
Volume | 200µl |
Concentration | 0.50µg/µlinantibodystABIlizationbuffer |
Form | AffinityPurified |
Clonality | Polyclonal |
Determinant | C-epitope |
Storage | -20⁰Cforlongtermstorage |
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ConfocalMicroscopy |
1:200 |
DB | 1:20,000 |
ELISA | 1:20,000 |
Immunocytochemistry | 1:200 |
Immunofluorescence | 1:200 |
Immunohistochemistry | 1:200 |
WesternBlot | 1:500 |
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Uniprot# |
P05111 |
Overview | Inhibinsandactivinsinhibitandactivate,respectively,thesecretionoffollitropinbythepituitarygland.Inhibins/activinsareinvolvedinregulatinganumberofdiversefunctionssuchashypothalamicandpituitaryhormonesecretion,gonadalhormone |
MolecularFunction | Cytokineactivity,hormoneactivity,growthfactoractivity,receptorbinding |
SubcellularLocation | Secreted |
Expression | Originallyfoundinovary(granulosacells)andtestis(Sertolicells),butwidelydistributedinmanytissuesincludingbrainandplacenta.Inadrenalcortexexpressionislimitedtothezonareticularisandtheinnermostzonafasciculatainthenormalgland,extendingcentripetallyintothezonafasciculatainhyperplasia.Alsofoundinadrenocorticaltumors.Alsoexpressedinprostateepitheliumofbenignprostatichyperplasia,inregionsofbasalcellhyperplasiaandinnonmalignantregionsofhighgradeprostatecancer.OnlycirculatinginhibinBisfoundinmale,whereascirculatinginhibinsAandBarefoundinfemale. |
AlternativeNomenclature | Ainhibinsubunitprecursorantibody IHAantibody inhAantibody Inhibinalphachainantibody Inhibinalphachainprecursorantibody |