FabGennix/KIRREL Antibody/NEPH1121AP/

GeneralInformation

Product

KIRRELAntibody

Description

AffinityPurifiedKinofIRRE-likeprotein1Antibody

VerifiedApplications

CM,ELISA,ICC,IF,IHC,IP,WB

Host

Rabbit

SpeciesCrossReactivity

Mouse,Rat

Immunogen

Recombinantprotein

PhysicalProperties

Quantity

100µg

Volume

200µl

Concentration

0.45-0.65µg/µlinantibodystabilizationbuffer

Form

AffinityPurified

Clonality

Polyclonal

Storage

-20⁰Cforlongtermstorage

ApplicationProtocol

ConfocalMicroscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

WesternBlot

1:250

Protein

Uniprot#

Q80W68

Overview

Playsasignificantroleinthenormaldevelopmentandfunctionoftheglomerularpermeability.IsasignalingproteinthatneedsthepresenceofTECkinasestofullytrans-activatethetranscriptionfactorAP-1.

MolecularFunction

MyosinBinding

SubcellularLocation

Cellmembrane;Single-passtypeImembraneprotein

Expression

Abundantlyexpressedinkidney.Specificallyexpressedinpodocytesofkidneyglomeruli.

Structure

InteractswithTJP1/ZO-1andwithNPHS2/podocin(viatheC-terminus).InteractswithNPHS1/nephrin(viatheIg-likedomains);thisinteractionisdependentonKIRRELglycosylation.Homodimer(viatheIg-likedomains).Interactswhentyrosine-phosphorylatedwithGRB2.

AlternativeNomenclature

FLJ10845antibody

KinofIRRElike(Drosophila)antibody

KinofIRRElikeantibody

Kinofirregularchiasm-likeprotein1antibody

Kirrelantibody

MGC129542antibody

MGC129543antibody

NEPH1antibody

Nephrinlikeprotein1antibody

Nephrinrelatedantibody