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GeneralInformation |
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Product |
PERKAntibody |
Description | AffinityPurifiedEukaryotictranslationinitiationfactor2-alphakinase3Antibody |
VerifiedApplications | DB,ELISA,IHC,IP, WB |
Host | Rabbit |
SpeciesCrossReactivity | Human,Mouse,Rat |
Immunogen | Syntheticpeptidetakenwithinaminoacidregion1000-1050onhumanEukaryotictranslationinitiationfactor2-alphakinase3protein. |
Accession# | NCBI: NP_004827 |
| |
Quantity |
100µg |
Volume | 200µl |
Concentration | 0.68-0.70µg/µlinantibodystabilizationbuffer |
Form | AffinityPurified |
Clonality | Polyclonal |
Storage | -20⁰Cforlongtermstorage |
| |
DB | 1:4,000 |
ELISA | 1:4,000 |
| Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation | 1:150 |
WesternBlot | 1:500 |
| |
Uniprot# |
Q9NZJ5 |
Overview | Phosphorylatesthealphasubunitofeukaryotictranslation-initiationfactor2(EIF2),leadingtoitsinactivationandthustoarapidreductionoftranslationalinitiationandrepressionofglobalproteinsynthesis.Servesasacriticaleffectorofunfoldedproteinresponse(UPR)-inducedG1growtharrestduetothelossofcyclin-D1(CCND1).Involvedincontrolofmitochondrialmorphologyandfunction. |
MolecularFunction | Kinase,Serine/threonine-proteinkinase,Transferase |
SubcellularLocation | Endoplasmicreticulummembrane;Single-passtypeImembraneprotein |
Expression | Ubiquitous.Ahighlevelexpressionisseeninsecretorytissues. |
Structure | FormsdimerswithHSPA5/BIPinrestingcells.OligomerizesinER-stressedcells.InteractswithDNAJC3andMFN2. |
AlternativeNomenclature | Eif2ak3antibody Eukaryotictranslationinitiationfactor2alphakinase3antibody HemeregulatedEIF2alphakinaseantibody HRIantibody HsPEKantibody PancreaticeIF2alphakinaseantibody PEKantibody PRKRlikeendoplasmicreticulumkinaseantibody WRSantibody |