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GeneralInformation |
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Product |
EphrinReceptorA3Antibody |
Description | AffinityPurifiedEphrinType-AReceptor3Antibody |
VerifiedApplications | ELISA,IP,WB |
Host | Rabbit |
SpeciesCrossReactivity | Human,Mouse,Rat |
Immunogen | Syntheticpeptidetakenwithinaminoacidregion900-980onhumanEPHA3protein |
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Quantity |
100µg |
Volume | 200µl |
Concentration | 0.55-0.75µg/µlinantibodystabilizationbuffer |
Form | AffinityPurified |
Clonality | Polyclonal |
Storage | -20⁰Cforlongtermstorage |
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DB | 1:10,000 |
ELISA | 1:10,000 |
| Immunoprecipitation | 1:200 |
WesternBlot | 1:500 |
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Uniprot# |
P29320 |
Overview | Receptortyrosinekinasewhichbindspromiscuouslymembrane-boundephrinfamilyligandsresidingonadjacentcells,leadingtocontact-dependentbidirectionalsignalingintoneighboringcells.Thesignalingpathwaydownstreamofthereceptorisreferredtoasforwardsignalingwhilethesignalingpathwaydownstreamoftheephrinligandisreferredtoasreversesignaling. |
MolecularFunction | ATPbinding;Nucleotidebinding |
SubcellularLocation | Isoform1: Cellmembrane;Single-passtypeImembraneprotein. Isoform2: Secreted |
Expression | Widelyexpressed.Highestlevelinplacenta. |
Structure | Heterotetrameruponbindingoftheligand.Theheterotetrameriscomposedofanephrindimerandareceptordimer.Oligomerizationisprobablyrequiredtoinducebiologicalresponses.FormsaternaryEFNA5-EPHA3-ADAM10complexmediatingEFNA5extracellulardomainshedding. |
AlternativeNomenclature | AW492086antibody Cek4antibody EC2.7.10.1antibody EK4antibody End3antibody EphreceptorA3antibody EPH-likekinase4antibody EPH-liketyrosinekinase1antibody EphA3antibody Ephrintype-Areceptor3antibody ETK1antibody ETKantibody HEK4antibody HEKantibody Humanembryokinase1antibody Mek4antibody MGC109882antibody ReceptortyrosinekinaseHEKantibody Tyro4antibody Tyrosine-proteinkinaseTYRO4antibody |