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GeneralInformation |
|
Product |
TLR5Antibody |
Description | AffinityPurifiedToll-likereceptor5Antibody |
VerifiedApplications | ELISA,IP, WB |
Host | Rabbit |
SpeciesCrossReactivity | Human |
Immunogen | Syntheticpeptidetakenwithinaminoacidregion195-225onhumanTLR5protein. |
| |
Quantity |
100µg |
Volume | 200µl |
Concentration | 0.75µg/µlinantibodystabilizationbuffer |
Form | AffinityPurified |
Clonality | Polyclonal |
Storage | -20⁰Cforlongtermstorage |
| |
DB | 1:20,000 |
ELISA | 1:20,000 |
| Immunoprecipitation | 1:200 |
WesternBlot | 1:500 |
| |
Uniprot# |
O60602 |
Overview | Participatesintheinnateimmuneresponsetomicrobialagents.Mediatesdetectionofbacterialflagellins.ActsviaMYD88andTRAF6,leadingtoNF-kappa-Bactivation,cytokinesecretionandtheinflammatoryresponse. |
MolecularFunction | Receptor,interleukin-1receptorbinding,transmembranesignallingreceptoractivity |
SubcellularLocation | Membrane;Single-passtypeImembraneprotein |
Expression | Highlyexpressedinovaryandinperipheralbloodleukocytes,especiallyinmonocytes,lessinCD11c+immaturedendriticcells.Alsodetectedinprostateandtestis. |
Structure | BindsMYD88viatheirrespectiveTIRdomains.Homodimerbothintheabsenceandpresenceofligand. |
AlternativeNomenclature | SLEB1antibody TIL3antibody Tolllikereceptor5antibody Toll/interleukin1receptorlikeprotein3antibody |