FabGennix/Src Antibody/Src112AP/

GeneralInformation

Product

SrcAntibody

Description

Proto-oncogenetyrosine-proteinkinaseSrcAntibodyC-epitope

VerifiedApplications

CM,ELISA,IF,IHC,IP,WB

Host

Rabbit

SpeciesCrossReactivity

Human,Mouse,Rat

Immunogen

Syntheticpeptidetakenwithinaminoacidregion400-500onhumanSrcprotein.

Accession#

NCBI: NP_005408.1

PhysicalProperties

Quantity

100µg

Volume

200µl

Concentration

0.56-0.60µg/µlinantibodystabilizationbuffer

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰Cforlongtermstorage

ApplicationProtocol

ConfocalMicroscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:250

WesternBlot

1:500

Protein

Uniprot#

P12931

Overview

Participatesinsignalingpathwaysthatcontroladiversespectrumofbiologicalactivitiesincludinggenetranscription,immuneresponse,celladhesion,cellcycleprogression,apoptosismigration,andtransformation.

MolecularFunction

ATPbinding,ephrinreceptorbinding,hemebinding,ionchannelbinding,enzymebinding,growthfactorreceptorbinding,integrinbinding,kinaseactivity

SubcellularLocation

Cellmembrane,mitochondrioninnermembrane,nucleus,cytoplasm(Note:Localizestofocaladhesionsitesfollowingintegrinengagement.LocalizationtofocaladhesionsitesrequiresmyristoylationandSH3domain.)

Expression

Expressedubiquitously.Platelets,neuronsandosteoclastsexpress5-foldto200-foldhigherlevelsthanmostothertissues.

Structure

Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.SRCsubfamily.Contains1proteinkinasedomain.Contains1SH2domain.Contains1SH3domain.

AlternativeNomenclature

ASVantibody

Aviansarcomavirusantibody

cSRCantibody

CDNAFLJ14219fiscloneNT2RP3003800highlysimilartoRattusnorvegicustyrosineproteinkinasepp60csrcmRNAantibody

EC2.7.10.2antibody

NeuronalCSRCtyrosinespecificproteinkinaseantibody

NeuronalSRCantibody

OncogeneSRCantibody

p60Srcantibody

Proto-oncogenetyrosine-proteinkinaseSrcantibody

SRCprotooncogenenonreceptortyrosinekinaseantibody

SRC1antibody

Tyrosinekinasepp60csrcantibody

TyrosineproteinkinaseSRC1antibody

vsrcaviansarcoma(SchmidtRuppinA2)viraloncogenehomologantibody