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| General Information |
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Product |
MAPK3 Antibody |
| Description | Affinity Purified Mitogen-activated protein kinase 3 Antibody |
| Verified Applications | ELISA, IP, WB |
| Host | Chicken |
| Species Cross Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide taken within amino acid region 300-350 on human Mitogen-activated protein kinase 3. |
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Quantity |
100 µg |
| Volume | 200 µl |
| Concentration | 0.5 µg/µl in antibody stabilization buffer |
| Immunoglobulin | IgY |
| Form | Affinity Purified |
| Clonality | Polyclonal |
| Storage | -20⁰C for long term storage |
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ELISA |
1:10,000 |
| Immunoprecipitation | 1:150 |
| Western Blot | 1:500 |
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Uniprot # |
P27361 |
| Overview | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. |
| Molecular Function | Kinase, Serine/threonine-protein kinase, Transferase |
| Subcellular Location | Cytoplasm, Nucleus |
| Structure | The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. |
| Alternative Nomenclature | Mitogen-activated protein kinase 3 Antibody MAP kinase 3 Antibody MAPK 3 Antibody ERT2 Antibody Extracellular signal-regulated kinase 1 Antibody ERK-1 Antibody Insulin-stimulated MAP2 kinase Antibody MAP kinase isoform p44 Antibody p44-MAPK Antibody Microtubule-associated protein 2 kinase Antibody p44-ERK1 Antibody MAPK3 Antibody ERK1 Antibody PRKM3 Antibody |