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Signosis/Neurodegenerative Disease TF Activation Profiling Plate Array /FA-1013/1 Ea

Description:

Neurodegenerativedisease,includeParkinson’s,Alzheimer’sandHuntington’sdisease,isadiseasethatdirectlyaffecttheneuronsinthehumanbrain,whichresultinprogressivedegenerationand/ordeathofnervecells.Thisdiseaseisassociatedwiththeaccumulationofmisfoldedproteinswhichaffectproteostasis.Multipletranscriptionfactorsandtargetgeneshavebeenwidelyreportedtoassociatewithproteostasis,includingproteinsynthesis,folding,traffickinganddegradation.SignosishasdevelopedNeurodegenerativeDiseaseTranscriptionFactorActivationPlateArraytoanalyzetheactivitiesof15NeurodegenerativeDisease-relatedTFssimultaneouslyinmammaliansamples,includingAP1,CREB,ER,FOXO,FOXA1,GATA,HSF1,NFKB,NRF2,NRRR1,PITX3,PPAR,SP1,TBP,XBP1.

ApplicableGrid:

 ListofApplicableTFs:

 123456789101112
AAP1NRF2AP1NRF2AP1  NRF2AP1  NRF2AP1NRF2AP1NRF2 
BCREBNURR1CREBNURR1CREB  NURR1CREB  NURR1   CREB  NURR1 CREB  NURR1 
CERPITX1ERPITX1ER PITX1 ER   PITX1ER  PITX1 ER  PITX1 
DFOXO1PPARFOXO1PPARFOXO1  PPARFOXO1  PPAR FOXO1  PPAR  FOXO1PPAR 
EFOXA1SP1FOXA1SP1FOXA1  SP1FOXA1 SP1 FOXA1  SP1    FOXA1  SP1 
FGATATBXGATATBXGATA TBX GATA  TBX   GATA TBX  GATA  TBX 
GHSF1XBP-1HSF1XBP-1HSF1 XBP-1  HSF1 XBP-1   HSF1 XBP-1 HSF1 XBP-1 
HNFkBBlankNFkBBlank NFkB Blank NFkB Blank NFkB Blank NFkB Blank
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