Description of Neuron Device in DetailNat Methods. 2005 Aug;2(8):599-605.A microfluidic culture platform for CNS axonal injury, regeneration and transport.Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL.100umNeuronThe Neuron Device offered by XonamicrofluidicsLLCisfabricatedoutofopticallytransparentandBIOLOGicallyinertPolydimethylsiloxane(PDMS).TheNeuronDeviceconsistsoftwochambersconnectedbymicrogrooves.TheneurondevicealsomakesitpossIBLefortheresearchertofluidicallyisolatecellbodiesfromaxons.Thedeviceconsistsoftwochambersconnectedbyamuchsmallermicrogroovebarrier.Thehydrostaticpressurebetweenthetwochambersseparatedbythemicrogroovesallowstheresearchertofluidicallyisolateeachchamber.Thisisaccomplishedbykeepingthevolumesinthewellsononesideofthedevicehigherthantheothersideofthedevice.Thedifferenceinvolumecreateshydrostaticpressurethusfluidicallyisolatingeachcompartment.Thetotalvolumeofthedeviceisabout600ulthustheresearcheruseslessoftheexpensivereagentstypicallyusedinneuronalculture.Theneurondevicealsomakesitpossibletoperformaxotomy,cuttingaxonsviavacuumaspirationinthedistalchamberandobservingtheirregrowth.xonamicrofluidicsllcsnd150神经元突触细胞微灌流系统xonamicrofluidicsllcsnd450神经元突触细胞微灌流系统xonamicrofluidicsllcsnd900神经元突触细胞微灌流系统xonamicrofluidicsllcTCND500神经元突触细胞微灌流系统xonamicrofluidicsllcTCND1000神经元突触细胞微灌流系统xonamicrofluidicsllcRD150神经元突触细胞微灌流系统xonamicrofluidicsllcRD450神经元突触细胞微灌流系统xonamicrofluidicsllcRD900神经元突触细胞微灌流系统xonamicrofluidicsllcULP神经元突触细胞微灌流系统