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| Synonyms | MonoclonalTBCBantibody,AntiTBCBantibody,TubulinfoldingcofactorBantibody,CG22antibody,CKAP1antibody,CKAPIantibody |
|---|---|
| Specificity | Human |
| Applications | ELISA,WB |
| Immunogen | TBCBantibodywasraisedinmouseusingrecombinanthumanTBCB(1-244aa)purifiedfromE.coliastheimmunogen |
| Host | Mouse |
|---|---|
| Clone | AT1F6 |
| Isotype | IgG2b,k |
| Source | TBCBantibodyisderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanTBCBprotein. |
| MethodofPurification | TBCBantibodyispurifiedbyProteinAaffinitychromatography |
| Form&Buffer | SuppliedasliquidinPBS(pH7.4)containing10%glycerol,0.02%NaN3. |
| Concentration | 1mg/ml |
| Storage | Storeat4degCshortterm.Forlongtermstorage,aliquotandstoreat-20degCandavoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | Recommendedstartingdilutionis1:1500 |
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| BiologicalSignificance | TubulinfoldingcofactorB,alsoknownasTBCB,belongstotheMicrotubulesfamily.Biosynthesisoffunctionalmicrotubulesinvolvetheparticipationofseveralchaperones,termedTubulinfoldingcofactorsA(TBCA),B(TBCB),D(TBCD),E(TBCE)andC(TBCC),thatactonfoldingintermediatesdownstreamofthecytosolicchaperon,alternativelynamedTCP.TBCBisa244aminoacidcytoplasmicproteincontainingoneCAP-Glydomainandinwidelyexpressed.TBCBisinvolvedintheregulationoftubulinheterodimerdissociationandmayfunctionasanegativeregulatorofaxonalgrowth. |
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