Research Models

Molecular Innovations is pleased to introduce a variety of knockout mouse and mutant mouse animal research models. These mice are useful for many research and commercial applications including monoclonal antibody development, cardiovascular studies, and pharmaceutical development and testing. We can also collect plasma and organs from these unique mice. Knockout mice are created by targeted disruption of the gene of interest followed by extensive breeding to achieve homozygous mutants. Mutations are confirmed by PCR genotyping and functional assays. We have additional strains in development and can accommodate new custom projects. Click here for general inquiries regarding our mouse program, licensing options, and custom work.

IMMEDIATELY AVAILABLE STRAINS
C1 Inhibitor Knockout Mice (Hereditary Angioedema Research Model)
Factor IX Knockout Mice (Hemophilia B Research Model)
Factor X Knockout Mice
Factor XI Knockout Mice
Factor XII Knockout Mice
Kininogen Knockout Mice
Prekallikrein Knockout Mice
PAI-1 Knockout Mice
tPA Knockout Mice
VEGFB Knockout Mice

STRAINS IN BREEDING
PAI-1 Knockin Mice

Latest Articles

• A First Grader and His Diabetic Service Dog Gunner October 29, 2019 by Dr. Yang Liu
• GOT C1 Inhibitor? May 14, 2019 by Dr. Robert Blackburn
• Genome Editing Sheds a Light on the Treatment of Patients with Alpha1-Antitrypsin Deficiency April 29, 2019 by Dr. Yang Liu
• Japanese Black Rice Vinegar Kurozu May Have Antithrombotic Effects April 15, 2019 by Dr. Yang Liu
• Horse Kallikrein Inhibitor Comparison Study April 2, 2019 by Dave Ginsberg, MS

Latest Citations

• Semen Extracellular Vesicles From HIV-1–Infected Individuals Inhibit HIV-1 Replication In Vitro, and Extracellular Vesicles Carry Antiretroviral Drugs In Vivo March 7, 2020
• Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa March 7, 2020
• ENHANCING PLASMIN ACTIVITY TO PREVENT SOFT TISSUE CALCIFICATION [Patent] March 23, 2019
• Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition March 16, 2019
• PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease March 12, 2019

Newest Products

• Human TAFI Antigen ELISA Kit
• Bovine alpha-thrombin
• Human Cystatin C, C-terminal 10x His tag
• Hemopexin, Human Plasma
• Human Apolipoprotein E ELISA Kit
• VEGFB Knockout Mice

Molecular Innovations, founded in 1990, is a primary manufacturer of research antibodies, proteins and ELISA kits. We specialize in coagulation and thrombolysis reagents including PAI-1, tPA, urokinase, clotting factors, vitronectin, fibrinogen, fibronectin, prorenin/renin, prekallikrein, kallikrein, albumin, plasminogen, plasmin, antiplasmin, thrombin, antithrombin, complement components, and immunoglobulins. We offer a complete line of molecular biology reagents including DNA polymerases and competent cells. Now featuring knockout mouse and mutant mouse animal research models such as C1 Inhibitor knockouts (Hereditary Angioedema), Factor IX knockouts (Hemophilia B), prekallikrein knockouts, point mutations, and transgenic mice. Our customers all over the world include pharmaceutical and biotechnology companies as well as major research institutions. We offer custom projects and bulk quotes. All products are manufactured under stringent quality control standards at our new state of the art facility in Novi, MI, USA.