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U-protein/platelet derived growth factor β, human/P001/100 microgram

recombinantPDGFβ,human,0.1mg

Producedinamammaliancellline.

Alternativename:
pdgf
PDGF2
becaplermin
proto-oncogenec-Sis

Sendanemailtoinfo@U-proteinexpress.comforbulkquantities

Productdescription
HumanPDGFb,plateletderivedgrowthfactor(pdgf),isadimericprotein.ItcanformhomodimersofPDGFborheterodimerswithPDGFa.Itisinvolvedintheregulationofembryonicdevelopment,cellproliferation,cellmigration,survivalandchemotaxis.Potentmitogenforcellsofmesenchymalorigin.Requiredfornormalproliferationandrecruitmentofpericytesandvascularsmoothmusclecellsinthecentralnervoussystem,skin,lung,heartandplacenta.Requiredfornormalbloodvesseldevelopment,andfornormaldevelopmentofkidneyglomeruli.Playsanimportantroleinwoundhealing.MutationsinPDGFbareassociatedwithmeningioma.Reciprocaltranslocationsbetweenchromosomes22and7,atsiteswherethisgeneandthatforCOL1A1arelocated,areassociatedwithaparticulartypeofskintumorcalleddermatofibrosarcomaprotuberansresultingfromunregulatedexpressionofgrowthfactor.
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