产品资料

avivasysbio/Anti-Metabotropic Glutamate Receptor 5/1a (OAPC00080)/OAPC00080/100 ul

Gene Symbol:

GRM5

NCBI Gene Id:

24418

Protein Name:

Metabotropic glutamate receptor 5

Swissprot Id:

P31424

Protein Accession #:

NP_058708.1

Replacement Item:

This antibody may replace item sc-135682 from Santa Cruz Biotechnology.

Description of Target:

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).

Molecular Weight:

~125/250kDa

Host:

Rabbit

Clonality:

Polyclonal

Purification:

Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Application:

WB, IHC

Tissue Tool:

Find tissues and cell lines supported by DNA array analysis to express GRM5.

RNA Seq:

Find tissues and cell lines supported by DNA array analysis to express GRM5.

Immunogen:

Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.

Predicted Species Reactivity:

Human, Mouse, Rat

Predicted Homology Based on Immunogen Sequence:

Human; Mouse; Rat

Product Format:

Liquid. 100 ul in 200 mM Tris-Glycine (pH 7.5), 0.1% sodium azide. Adequate amount of material to conduct 10-mini Western Blots.

Reconstitution and Storage:

For long term storage -20C is recommended. Stable at -20C for at least 1 year.

Datasheets/Manuals:

Printable datasheet for OAPC00080

Specificity:

Specific for the ~125k monomer and the ~250k dimers of mGluR5 and mGluR1. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to generate the antibody.

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avivasysbio/Anti-Metabotropic Glutamate Receptor 5/1a (OAPC00080)/OAPC00080/100 ul