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avivasysbio/ADAM15 Antibody (OASL00958)/100ul/OASL00958

Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB
Additional Information:
Background: ADAM15 belongs to a family of transmembrane proteins that contain disintegrin and metalloprotease domains. Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 
:::
Positive Tissue: brain, lung, heart
Reconstitution and Storage:
Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Immunogen:
KLH conjugated Synthetic peptidecorresponding to Mouse ADAM15
Purification:
Affinity purification
Datasheets/Manuals:
Printable datasheet for OASL00958
Application Info:
WB: 1:500 - 1:1000
Gene Symbol:
ADAM15
Alias Symbols:
ADAM15, MDC15, ADAM metallopeptidase domain 15
Protein Name:
Disintegrin and metalloproteinase domain-containing protein 15
Swissprot Id:
O88839, Q13444, Q9QYV0
Molecular Weight:
93 kDa
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