Tested Species Reactivity:HumanProduct Format:LyophilizedApplication:CAAdditional Information:Description: Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors. Lin28 is found abundantly in embryonic stem cells (ESCs), and to a lesser extent in placenta and testis. Lin28 has been shown to block let-7 microRNA processing and maturation, a necessary step in the differentiation of stem cells and certain cancer cell lines.:::Bioactivity: Measured by its ability to induce fluorescence in Lin28 reporter cells (293 cells transfected with fluorescent protein genes under Lin28 control). Optimum activity was achieved at 20 ug/ml after incubation for 72 hr.:::Endotoxin Level: Endotoxin level is <0.1 ng/ug="" of="" protein=""><1>Reconstitution and Storage:-20CPurity:90%Protein Sequence:GPSVSNQQFA GGCAKAAEEA PEEAPEDAAR AADEPQLLHG AGICKWFNVR MGFGFLSMTA RAGVALDPPV DVFVHQSKLH MEGFRSLKEG EAVEFTFKKS AKGLESIRVT GPGGVFCIGS ERRPKGKSMQ KRRSKGDRCY NCGGLDHHAK ECKLPPQPKK CHFCQSISHM VASCPLKAQQ GPSAQGKPTY FREEEEEIHS PTLLPEAQNG GYGRKKRRQR RRSource:E.coliTarget Reference:Fu Y, Gao L, Shi Z, You F, Zhang J, Li W. Fish Physiol Biochem. 2017 Dec 7. doi: 10.1007/s10695-017-0445-1. Chandrasekaran S, Zhang J, Sun Z, Zhang L, Ross CA, Huang YC, Asara JM, Li H, Daley GQ, Collins JJ. Cell Rep. 2017 Dec 5;21(10):2965-2977. doi: 10.1016/j.celrep.2017.07.048.Datasheets/Manuals:Printable datasheet for OPTA01107Alias Symbols:CSDD1, LIN28A, ZCCHC1Molecular Weight:24.4 kDa
