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ApexBio/RS 504393/5mg/A3779

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Molarity CalculatorDilution Calculator
RS 504393CCR2 chemokine receptor antagonist

Catalog No.A3779
SizePriceStockQty
5mg
$119.00
In stock
10mg
$194.00
In stock
25mg
$432.00
In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Product Citations

1. Jinghua Jiang , Fei Ye, et al. "Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells." Cancer Letters.17 July 20171/10.

Quality Control

Quality Control & MSDS

View current batch:
    Purity = 98.00%
  • COA (Certificate Of Analysis)
  • MSDS (Material Safety Data Sheet)

Chemical structure

RS 504393

Related Biological Data

RS 504393

RS 504393 Dilution Calculator

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Chemical Properties

Cas No. 300816-15-3SDF Download SDF
Synonyms RS-504393; RS504393
Chemical Name 6-methyl-1"-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4"-piperidin]-2(1H)-one
Canonical SMILES CC1=CC2=C(NC(OC23CCN(CCC4=C(C)OC(C5=CC=CC=C5)=N4)CC3)=O)C=C1
Formula C25H27N3O3 M.Wt 417.5
Solubility Soluble in DMSO Storage Store at -20°C
Physical AppearanceA solidShipping ConditionEvaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). RS 504393 inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
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