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tecomedical/Monoclonal Antibodies/1/A255

Monoclonal Antibodies

Product name

Monoclonal Antibody to Human Factor H#3

A murine monoclonal antibody to human Factor H

Cat-Nr.A255
Intended use

Specifications: Isotype: IgG1k Protein Concentration: 1.0 - 1.2 mg/ml Volume/Vial: 100 µl Storage: ≤ 30 days 2 - 8 °C > 30 days ≤ -20 °C

Specificity: This monoclonal antibody was raised against purified human Factor H. Studies have shown that this antibody functionally inhibits Factor H.

Applications: Quidel's Factor H monoclonal antibody has been used in a variety of experimental techniques including EIA and Western Blot.

References:

  • Pangburn MK, Differences between the binding sites of the complement regulatory proteins DAF, CR1 and Factor H on C3 Convertases, J Immunol 136:6 (1986).
  • Kraiczy P, R. Würrzner, Complement escape of human pathogenic bacteria by acquisition of complement regulators, Mol Immunol 43:31-44 (2006).
  • John P. Atkinson and Timothy H.J. Goodship, Complement factor H and the hemolytic uremic syndrome, JEM 204:6, June 11, 1245-1248 (2007).
  • Sivaprasad S. and NV Chong, The Complement system and age related macular degeneration, Eye 1-6 (2006).
  • Jokiranta, TS, et al., Analysis of the recognition mechanism of the alternative pathway of complement by monoclonal anti factor H antibodies: evidence for multiple interactions between H and surface bound C3b, FEBS Ltr 393(2-3):297-302 (1996).
  • Junnikkala S. et al., Exceptional resistance of Human H2 Glioblastoma Cells to Complement Mediated Killing by Expression and Utilization of Factor H and Factor H Like Protein I, J Immunol 164(2000).
  • Cheng Z. et al., Complement Factor H as a Marker for Detection of Bladder Cancer, Clin Chem 51:5 (2005).

Product informations
Datasheet (PDF 752,1 kB)

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