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ViennaLab/KRAS & NRAS/20 tests/5-620

Monoclonal antibody (mAb) therapies targeting epidermal growth factor receptor (EGFR) are used in metastatic colorectal cancer (mCRC) therapies. KRAS and NRAS StripAssays® identify the most relevant genetic variants of KRAS and NRAS genes interfering with treatment/therapy success.

KRAS & NRAS

  • Inhibiting EGFR with anti-EGFR mAbs prevents activation of the relevant signal transduction pathway. However, certain mutations in RAS genes result in permanent activation of parts of this pathway, rendering anti-EGFR therapies ineffective.
  • Prior to treatment with anti-EGFR mAbs, mCRC patients should be tested for RAS variants, as positive patients are unlikely to benefit from this kind of therapy.
  • KRAS and NRAS StripAssays® assist clinicians in the stratification of patients considered for anti-EGFR mAb therapies (i.e. cetuximab or panitumumab).

ProductREFUnit SizeIFUBrochure
KRAS XL StripAssay®5-68020 tests

PDF

PDF

NRAS XL StripAssay®5-62020 tests

PDF

PDF

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