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| 1 | ProstaglandinESignalingandBacterialInfectionRecruitTumor-PromotingMacrophagestoMouseGastricTumors | 日本金沢大学癌症研究所 | Gastroenterology | 12.9 | EphB3 |
| 2 | RN181suppressedtumorgrowthofhepatocellularcarcinomabyinhibitionoftheERK/MAPKpathway | 南方医科大学 | Hepatology | 10.8 | activatedcaspase3bs7004 |
| 3 | Cholesterolsequestrationbynystatinenhancestheuptakeandactivityofendostatininendotheliumviaregulatingdistinctendocyticpathways. | 清华大学 | Blood | 10.6 | BS1620TfR1 BS3547LaminB1 |
| 4 | D-peptideinhibitorsofthep53–MDM2interactionfortargetedmoleculartherapyofmalignantneoplasms | 美国马里兰大学 | PNAS | 9.4 | p53andMDM2 |
| 5 | Newinsightsintotheantifibroticeffectsofsorafenibonhepaticstellatecellsandliverfibrosis | 河北医科大学 | JHepatol | 7.8 | MMP-1andMMP-13 |
| 6 | PDK1RegulatesVascularRemodelingandPromotesEpithelial-MesenchymalTransitioninCardiacDevelopment | 南京大学模式动物研究所 | molecularandcellularBIOLOGy | 7.8 | BS1853SNAI1 |
| 7 | EndothelialcellsdysfunctioninducedbysilicananoparticlesthroughoxidativestressviaJNK/P53andNF-kBpathways | 上海交通大学 | Biomaterials | 7.4 | p-ERK,ERK,p-JNK,JNK,p-c-Jun,c-Jun |
| 8 | HOXB7asaprognosticfactorandmediatorofcolorectalcancerprogression | 南方医科大学 | ClinicalCancerResearch | 6.7 | p-ERK,ERK,p-AKT,AKT,p-GSK3β,GSK3β,CyclinD1andP27antibodies(BioworldTechnology,MN). |
| 9 | Endostatininhibitstumourlymphangiogenesisandlymphaticmetastasisviacellsurfacenucleolinonlymphangiogenicendothelialcells | 清华大学 | JPathol | 6.5 | BS1574PECAM-1 |
| 10 | SclerostinMediatesBoneResponsetoMechanicalUnloADIngThroughAntagonizingWnt/b-CateninSignaling | 上海交通大学 | journalofboneandmineralresearch | 6.0 | BS5056p-beta-catenin(S33S37T41) |
| 11 | UXT-V1protectscellsagainstTNF-inducedapoptosisthroughmodulatingcomplexIIformation | 中科院上海生命科学研究所 | MolBiolCell | 6.0 | BS1387Caspase-8、BS1478TNFR1 |
| 12 | TrioIsaKeyGuanineNucleotideExchangeFactorCoordinatingRegulationoftheMigrationandMorphogenesisofGranuleCellsintheDevelopingCerebellum | 南京大学模式动物研究所 | journalofbiologicalchemistry | 5.3 | Tau |
| 13 | HemeOxygenase-1/CarbonMonoxideInducesVascularEndothelialGrowthFactorExpressionviap38Kinase-dependentActivationofSp1 | 台湾医学科学院 | journalofbiologicalchemistry | 5.3 | phospho-Sp1-T739antibody(BS4755) |
| 14 | Slowskeletalmusclemyosinbindingprotein-C(MyBPC1)mediatesrecruitmentofmuscletypecreatinekinase(CK)tomyosin. | 清华大学 | BiochemicalJournalImmediatePublication | 5.1 | MM-CKBS1915 |
| 15 | SilencingofhHS6ST2inhibitsprogressionofpancreaticcancerthroughinhibitionofNotchsignaling | 中国药科大学 | BiochemicalJournalImmediatePublication | 5.1 | CD31 |
| 16 | Commongeneticvariantson8q24contributetosusceptibilitytobladdercancerinaChinesepopulation | 南京医科大学 | Carcinogenesis | 4.8 | MYC |
| 17 | MitochondrialProhibitinsandSeptin9AreImplicatedintheOnsetofRatHepatocarcinogenesis | 日本大阪市立大学医学部 | ToxicologicalSciences | 4.8 | BS1992HNF-4αγ |
| 18 | miR-106a–mediatedMalignantTransformationofCellsInducedbyAnti-benzo[a]pyrene-trans-7,8-diol-9,10-epoxide. | 广州医科大学 | ToxicolSci | 4.8 | RBGAPDH |
| 19 | IncreaseofAnteroventralPeriventricularKisspeptinNeuronsandGenerationofE2-InducedLH-SurgeSysteminMaleRatsExposedPerinatallytoEnvironmentalDoseofBisphenol-A. | 南京医科大学 | Endocrinology | 4.8 | Biotingoatantimouse |
| 20 | miR-181bmodulatesmultidrugresistancebytargetingBCL2inhumancancercelllines | 南京医科大学 | InternationalJournalofCancer | 4.7 | BCL2,b-actinanda-Tubulin |
| 21 | Adenoviral-mediatedRNAinterferencetargetingURG11inhibitsgrowthofhumanhepatocellularcarcinoma | 第四军医大学 | InternationalJournalofCancer | 4.7 | pRbBS4164 |
| 22 | Lymphaticendothelialcell-secretedCXCL1stimulateslymphangiogenesisandmetastasisofgastriccancer | 中山大学 | InternationalJournalofCancer | 4.7 | RhoA |
| 23 | p53suppresseslungresistance-relatedproteinexpressionthroughY-boxbindingprotein1intheMCF-7breasttumorcellline | 北京放射医学研究所 | JournalofCellularPhysiolo | 4.6 | anti-HDAC2 |
| 24 | 17b-EstradiolEnhancestheResponseofPlasmacytoidDendriticCelltoCpG | 南京大学 | PLoSONE | 4.3 | BS1754IFN-αβRα |
| 25 | LRP16IntegratesintoNF-kBTranscriptionalComplexandIsRequiredforItsFunctionalActivation | 解放军总医院 | PLoSONE | 4.3 | CARM1,P300/CBP |
| 26 | Mechanismsinvolvedinextraterritorialfacialpainfollowingcervicalspinalnerveinjuryinrats | 日本大学牙医部 | MolecularPain | 4.1 | BS5090p-NMDAR1(S896) |
| 27 | proteolyticreleaseofthereceptorforadvancedglycationendproductsfrominvitroandinsitualveolarepithelialcells. | 日本东京医科齿科大学 | LungCellularandMolecularPhysiology | 4.0 | MMP-13BS1238 |
| 28 | Luteolininhibitsinflammatoryresponseandimprovesinsulinsensitivityintheendothelium | 中国药科大学 | Biochimie | 3.9 | P-IRS-1、IRS-1、P-AKT、AKT、P-IKK、IKK、horseradishperoxidase(HRP)-labeledanti-rabbitIgG |
| 29 | DHEApreventsA25e35-impairedsurvivalofnewbornneuronsinthedentategyrusthroughamodulationofPI3K-Akt-mTORsignaling | 南京医科大学 | Neuropharmacology | 3.9 | phosphorp70S6k、p70S6k |
| 30 | 20(S)-GinsenosideRh2NoncompetitivelyInhibitsP-GlycoproteinInVitroandInVivo:ACaseforHerb-DrugInteractions | 中国药科大学 | DrugMetabolismandDisposition | 3.7 | BS6007Mβ-ActinmAb |
| 31 | Localhyperthermiacouldinduceantiviralactivitybyendogenousinterferon-dependentpathwayincondylomaacuminata | 中国医科大学 | AntiviralResearch | 3.6 | PKR、Stat1、Stat2 |
| 32 | PlasmaMembraneH+-ATPaseand14-3-3IsoformsofArABIdopsisLeaves:EvidenceforIsoformSpecificityinthe14-3-3/H+-ATPaseInteraction | 瑞典兰德大学 | PlantCellPhysiol | 3.6 | anti14-3-3 |
| 33 | GinsenosideRg1protectsagainsthydrogenperoxide-inducedcelldeathinPC12cellsviainhibitingNF-kBactivation | 中国药科大学 | NeuRochemistryInternational | 3.5 | p-p65,p65,p-IKKb,IKK,IkBa,p-IkBa,akt,p-akt,p-ERK,ERK |
| 34 | Loganinprotectsagainsthydrogenperoxide-inducedapoptosisbyinhibitingphosphorylationofJNK,p38,andERK1/2MAPKsinSH-SY5Ycells | 韩国成均馆大学 | NeurochemistryInternational | 3.5 | Rabbitanti-JNKandrabbitanti-ERK1/2MAPKsantibodies |
| 35 | Involvementofp120inLPS-inducedNF-BactivationandIL-8productioninhumanbronchialepithelialcells | 华中科技大学 | ToxicologyLetters | 3.5 | PhosphorylatedIkBa(S32+S36) |
| 36 | InvolvementofJNKandP53ActivationinG2/MCellCycleArrestandApoptosisinducedbyTitaniumDioxideNanoparticlesinneuroncells | 上海交通大学 | ToxicologyLetters | 3.5 | p-JNK,JNK,p-c-Jun,c-Jun、p-p53、bcl2、bax |
| 37 | Asensitiveimmunoassaybasedondirecthaptencoatedformatandbiotin-streptavidinsystemforthedetectionofchloramphenicol | 华中农业大学 | Talanta | 3.3 | HRP-SPA? |
| 38 | Interleukin-15receptor-directedimmunotoxinsatteunuatediseaseseverityinratadjuvantarthritis | 东南大学 | MolecularImmunology | 3.2 | phosphotyrosineSTAT3、STAT3 |
| 39 | Slit2-NinhibitsPDGF-inducedmigrationinratairwaysmoothmusclecells:WASPandArp2/3involved | 第二军医大学 | Toxicology | 3.2 | WASP |
| 40 | Gambogicacid-induceddegradationofmutantp53ismediatedbyproteasomeandrelatedtoCHIP | 中国药科大学 | JournalofCellularBiochemistry | 3.0 | Hsp90、ubiquitin |
| 41 | PI3KandERK/Nrf2pathwaysareinvolvedinoleanolicacid-inducedheme oxygenase-1expressioninratvascularsmoothmusclecells | 第三军医大学 | JournalofCellularBiochemistry | 3.0 | Aktandp-Akt |
| 42 | HSP75protectsagainstcardiachypertrophyandfibrosis | 武汉人民医院 | JournalofCellularBiochemistry | 3.0 | MB001GAPDH |
| 43 | MutationalandexpressionalanalysisofRFC3,aclamploaderinDNAreplication,ingastricandcolorectalcancers | 韩国天主教大学 | HumanPathology | 3.0 | RFC3 |
| 44 | Cdk1isrequiredfortheself-renewalofmouseembryonicstemcells | 首都师范大学 | JCellBiochem | 2.9 | Cdk1 |
| 45 | LPARescuesERStress-AssociatedApoptosisinHypoxiaandSerumDeprivation-Stimulated MesenchymalStemCells | 医科院阜外医院 | JCELLBIOCHEM | 2.9 | p-eIF2aand eIF2a |
| 46 | Ghrelin-AttenuatedCognitiveDysfunctioninStreptozotocin-inducedDiabeticRats.(全文暂无) | 美国德克萨斯大学 | AlzheimerDisease&AssociatedDisorders | 2.9 | p-ERK1/2 |
| 47 | EffectsoftheacidpolysaccharidefractionisolatedfromacultivatedCordycepssinensisonmacrophagesinvitro | 南京大学 | CellularImmunology | 2.7 | NF-kBp65monoclonal写成单抗了 |
| 48 | SpecificRoleofTightJunctionProteinsClaudin-5,Occludin,andZO-1oftheBlood–BrainBarrierinaFocalCerebralIschemicInsult | 中国医科大学 | JMolNeurosci | 2.7 | rabbitanti-PKCδ(diluted1:500;Bioworld) |
| 49 | TheregulatorymechanismofHsp90asecretionfromendothelialcellsanditsroleinangiogenesisduringwoundhealing | 清华大学 | BBRC | 2.6 | BS1574PECAM-1 |
| 50 | Differentiationofmouseembryonicstemcellsintodentalepithelial-likecellsinducedbyameloblastsserum-freeconditionedmedium | 第四军医大学 | BBRC | 2.6 | CK14 |
| 51 | RolesofWnt/b-cateninsignalinginepithelialdifferentiationofmesenchymalstemcells | 南京大学医学院 | BBRC | 2.6 | GSK3b,pi-GSK3b,catenin-b,pi-catenin-b、TCF3 |
| 52 | Transmissionofcirculatingcell-freeAAamyloidoligomersinexosomesvectorsviaaprion-likemechanism | 日本熊本大学 | BBRC | 2.6 | Tsg101 |
| 53 | hCLP46regulatesU937cellproliferationviaNotchsignalingpathway | 中国科学院生命科学学院 | BBRC | 2.6 | p-Rb(S780)pAb |
| 54 | Anti-invasiveeffectofgambogicacidinMDA-MB-231humanbreastcarcinomacells | 中国药科大学 | BiochemCellBiol | 2.6 | ERK12 |
| 55 | CryptotanshinonehasdiverseeVectsoncellcycleeventsinmelanomacelllineswithdiVerentmetastaticcapacity | 南京中医药大学 | CancerChemotherPharmacol | 2.6 | BS1053Chk1、BS1391Chk2、BS1804CyclinA1、BS1820Cdk1Cdc2 |
| 56 | Synergisticeffectof5-fluorouracilandtheflavanoidoroxylinAonHepG2humanhepatocellularcarcinomaandonH22transplantedmice | 中国药科大学 | CancerChemotherPharmacol | 2.6 | COX-2 |
| 57 | GambogenicacidmediatedapoptosisthroughthemitochondrialoxidativestressandinactivationofAktsignalingpathwayinhumannasopharyngealcarcinomaCNE-1cells | 安徽中医药大学 | EuropeanJournalofPharmacology | 2.6 | caspase-9 |
| 58 | Dexamethasoneenhancestrichosanthin-inducedapoptosisintheHepG2hepatomacellline | 浙江大学药学院 | LifeSciences | 2.6 | histoneH1 |
| 59 | AssociationofElevatedGRP78ExpressionwithIncreasedAstrocytomaMalignancyviaAktandERKPathways | 第四军医大学 | BrainResearch | 2.5 | GRP78 |
| 60 | Peroxisomeproliferator-activatedreceptorgammaagoNISTrosiglitazoneattenuatesoxyhemoglobin-inducedToll-likereceptor4expressioninvascularsmoothmusclecells | 南京大学 | BrainResearch | 2.5 | TLR4 |
| 61 | MicroRNA-10binducesgliomacellinvasionbymodulatingMMP-14and1uPARexpressionviaHOXD10 | 南京医科大学 | BrainResearch | 2.5 | HRP-conjugatedrabbitanti-goatsecondaryantibodies |
| 62 | EffectofCIPCandinterventionofCa2+-regulatedfactorsonCaN,cbl-bandp-AKTexpressioninneurons | 大连医科大学 | BrainResearch | 2.5 | AKT、p-AKT |
| 63 | SorafenibInducesGrowthInhibitionandApoptosisofHumanChondrosarcomaCellsbyBlockingtheRAF/ERK/MEKPathway | 北京人民医院 | JournalofSurgicalOncology | 2.5 | 1032Bcl-xl、1220Mcl-1、1310Rb |
| 64 | NGF/TrkA-mediatedKidins220/ARMSsignalingactivatedintheallergicairwaychallengeinmice | 中国医科大学 | AnnAllergyAsthmaImmunol | 2.4 | CrkL |
| 65 | AngiotensinType-1ReceptorBlockerCandesartanInhibitsCalciumOxalateCrystalDepositioninEthyleneGlycol-TreatedRatKidneys | 日本大阪大学 | Urology | 2.4 | TGF-β |
| 66 | Japaneseencephalitisvirusco-optstheER-stressresponseproteinGRP78forviralinfectivity | 台湾长庚大学 | VirologyJournal | 2.4 | anti-GRP78 |
| 67 | ModifiedSi-Miao-SanExtractinhibitsinflammatoryresponseandmodulatesinsulinsensitivityinhepatocytesthroughanIKKβ/IRS-1/Akt-dependentpathway | 中国药科大学 | JournalofEthnopharmacology | 2.3 | pIKKbpIRSIRSpAKTAKT |
| 68 | ModifiedSi-Miao-Sanextractinhibitsthereleaseofinflammatorymediatorsfromlipopolysaccharide-stimulatedmousemacrophages | 中国药科大学 | JournalofEthnopharmacology | 2.3 | IKB-a |
| 69 | Involvementofp38MAPKsignalingpathwayintheanti-melanogeniceffectofSan-bai-tang,aChineseherbalformula,inB16cells | 香港浸会大学 | JournalofEthnopharmacology | 2.3 | tyrosinase,MITFandTRP-2 |
| 70 | Integralpharmacokineticsofmultiplelignancomponentsinnormal,CCl4-inducedhepaticinjuryandhepatoprotectiveagentspretreatedratsandcorrelationswithhepaticinjurybioMarkers | 中国药科大学 | JournalofEthnopharmacology | 2.3 | 发光液ECL |
| 71 | UrsolicacidinducesHL60monocyticdifferentiationandupregulatesC/EBPbexpressionbyERKpathwayactivation | 中国药科大学 | Anti-CancerDrugs | 2.2 | anti-C/EBPbandanti-c-myc |
| 72 | Retinoicacidattenuateslipopolysaccharide-inducedinflammatoryresponsesbysuppressingTLR4/NF-κBexpressioninratmammarytissue | 南京农业大学 | InternationalImmunopharmacology | 2.2 | GAPDH |
| 73 | InhibitoryeffectofsiRNAtargetingIGF-1Ronendometrialcarcinoma | 中山大学 | InternationalImmunopharmacology | 2.2 | Ki67 |
| 74 | Flavonoids,apigeninandicariinexertpotentmelanogenicactivitiesinmurineB16melanomacells | 香港浸会大学 | Phytomedicine | 2.2 | tyrosinaseandTRP-2 |
| 75 | TanshinoneIIAattenuatesinflammatoryresponsesofratswithmyocardialinfarctionbyreducingMCP-1expression | 浙江大学 | Phytomedicine | 2.2 | TroponinI |
| 76 | TheneuroprotectiveeffectsofLonicerajaponicaTHUNB.againsthydrogenperoxide-inducedapoptosisviaphosphorylationofMAPKsandPI3K/AktinSH-SY5Ycells | 韩国成均馆大学 | FoodandChemicalToxicology | 2.1 | Rabbitanti-JNKandrabbitanti-ERK1/2MAPKsantibodies |
| 77 | c-JunN-terminalkinaseisinvolvedintheregulationofproliferationandapoptosisbyintegrin-linkedkinaseinhumanretinoblastomacells | 武汉大学 | GraefesArchClinExpOphthalmol | 2.1 | p-JNKJNKP-c-JUNc-JUN |
| 78 | CordycepssinensisExtractsAttenuateAorticTransplantArteriosclerosisinRats | 温州医学院 | JournalofSurgicalResearch | 2.1 | PCNA |
| 79 | Doubleantioxidantactivitiesofrosiglitazoneagainsthighglucose-inducedoxidativestressinhepatocyte | 第四军医大学 | ToxicologyinVitro | 2.1 | P-PKC, PKC, COX-2, PPAR, and p38 MAPK |
| 80 | SignaltransductionmechanismofTRB3inratswithnon-alcoholicfattyliverdisease | 上海长宁中心医院 | WorldJournalofGastroenterology | 2.1 | Akt(A444),p-Akt(S473)andp-Akt(T308) |
| 81 | NuclearFactor-KappaBActivityRegulatesBrainExpressionofP-GlycoproteinintheKainicAcid-InducedSeizureRats | 南京医科大学 | MediatorsofInflammation | 2.0 | antiphospho-NF-κBp65BS4135 |
| 82 | Inhibitionofvascularendothelialgrowthfactor-inducedangiogenesisbyscopoletinthroughinterruptingtheautophosphorylationofVEGFreceptor2anditsdownstreamsignalingpathways | 中国药科大学 | VascularPharmacology | 2.0 | p-VEGFR1,p-VEGFR2,VEGFR1,VEGFR2,p-AKT，AKT,p-eNOSandeNOS |