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Cellagentech/Skepinone-L | p38 MAPK inhibitor/C7537-2s/2 mg (10 mM solution in DMSO)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/Skepinone-L | p38 MAPK inhibitor/C7537-2s/2 mg (10 mM solution in DMSO)

ProductDescription

Skepinone-LisanATP-competitive,dibenzosuberone-basedinhibitorofp38-MAPKandTNF-a,withIC50valuesof5and40nM,respectively.[1]At1000nM,Skepinone-L(Kd=1.5nM)didnotinhibitanyothermemberofanAmbitpanelof402kinases.[2]

InvitroHeLacellassaysdeterminedthatSkepinone-Lshowedaconcentration-dependentinhibitionofHSP27(Ser82)phosphorylationatanIC50of25nM.[2].FurThermore,Skepinone-Lreducedconcentrationsofwellknownp38MAPKsubstrates,suchasIL-1bandIL10(IC50=30-50nM).[2]

Technicalinformation:

ChemicalFormula: C24H21F2NO4
CAS#: 1221485-83-1
MolecularWeight: 425.42
Purity: >99%
Appearance: Yellow
ChemicalName: (R)-2-((2,4-difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one
Solubility: Upto22mMinDMSO
Synonyms: Skepinone-L

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.Koeberleetal.,Design,synthesis,andBIOLOGicalevaluationofnoveldisubstituteddibenzosuberonesashighlypotentandselectiveinhibitorsofp38mitogenactivatedproteinkinase.J.Med.Chem.2012,55,5868-5877.PubmedID:22676210
2.Koeberleetal.,Skepinone-Lisaselectivep38mitogen-activatedproteinkinaseinhibitor.Nat.Chem.Biol.2012,8,141-143.PubmedID:22198732

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