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MSD Biomarker Assays Selected for Resveratrol Study in Alzheimer’s Disease
白藜芦醇治疗阿尔茨海默氏症，选择MSD生物标志物分析
马里兰州洛克维尔市,2014年5月23日, Meso Scale Discovery品牌-Meso Scale 诊断有限公司旗下品牌，MSD®今天宣布,其淀粉样多肽和Tau的分析技术被选择应用于神经退行性疾病的临床研究。
阿尔茨海默氏症(ADCS)合作研究机构在一项临床研究中测试白藜芦醇化合物（存在于红酒和红葡萄）是否有利于患有轻度至中度痴呆阿尔茨海默氏症。白藜芦醇有多个利于衰老相关的疾病的优点，但它在阿尔茨海默病中的作用需要进一步调查。
ADCS生物标志物核心实验室主任，罗伯特Rissman博士说, “我们已经验证MSD分析技术，并用于白藜芦醇试验中的主要endpoint分析及探索生物标志物”。在脑脊髓液(CSF)中的生物标志物，如淀粉样多肽和Tau,对于评价阿尔茨海默病的发生和发展,以及决定是否治疗是非常有效的。
“我们很高兴成为这个重要研究的一部分，我们在这些分析方法的投资体现了我们对于推动神经退行性疾病研究的承诺。” MSD公司的总裁兼首席执行官Jacob Wohlstadter说。
MSD发展神经退化分析生物标记已经好几年了,但现在能提供经过严格验证过的试剂盒，给阿尔茨海默氏症研究人员们提供了下一代更强大的精度和自动化的分析试剂盒。这些试剂盒足以支持临床研究和纵向研究。
“我们期待与MSD在脑脊液生物标志物的检测项目上合作。”保罗•爱森博士，ADCS主任。白藜芦醇试验包括26个美国学术机构隶属于ADCS。它是由国家衰老研究院的资助。
| V–PLEX Assays | ||||||
| Description | Capture | Detector | Species | Insert | Catalog | |
| Number | ||||||
| Aβ38 Peptide (4G8) | (V–PLEX) | Anti-Aβ38 | 4G81 (a.a. 17-24) | Rodent/Human | 96-well | K150SHE |
| K150SHG | ||||||
| Aβ38 Peptide (6E10) | (V–PLEX) | Anti-Aβ38 | 6E101 (a.a. 1-16) | Human | 96-well | K150SIE |
| K150SIG | ||||||
| Aβ40 Peptide (4G8) | (V–PLEX) | Anti-Aβ40 | 4G81 (a.a. 17-24) | Rodent/Human | 96-well | K150SJE |
| K150SJG | ||||||
| Aβ40 Peptide (6E10) | (V–PLEX) | Anti-Aβ40 | 6E101 (a.a. 1-16) | Human | 96-well | K150SKE |
| K150SKG | ||||||
| Aβ42 Peptide (4G8) | (V–PLEX) | Anti-Aβ42 | 4G81 (a.a. 17-24) | Rodent/Human | 96-well | K150SLE |
| K150SLG | ||||||
| Human Aβ42 | (V–PLEX) | Anti-Aβ42 | 6E101 (a.a. 1-16) | Human | 96-well | K151LBE |
| K151LBG | ||||||
| Human Total Tau 1 | (V–PLEX) | Tau | Human | 96-well | K151LAE | |
| K151LAG | ||||||
| Aβ Peptide Panel 1 (4G8)1 (Aβ38, Aβ40, Aβ42 Multiplex) | (V–PLEX) | Anti-Aβ38, Anti-Aβ40, | 4G81 (a.a. 17-24) | Rodent/Human | 96-well | K15199E |
| Anti-Aβ42 | K15199G | |||||
| Aβ Peptide Panel 1 (6E10)1 (Aβ38, Aβ40, Aβ42 Multiplex) | (V–PLEX) | Anti-Aβ38, Anti-Aβ40, | 6E101 (a.a. 1-16) | Human | 96-well | K15200E |
| Anti-Aβ42 | K15200G | |||||
| Description | Analytes | Species | Insert | Catalog | |
| Number | |||||
| Neuroinflammation Panel 1 (human) | (V–PLEX) | IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, TNF-α, IL-1α, | Human | 96-well | K15210D |
| IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF, Eotaxin, MIP-1β, Eotaxin-3, TARC, IP-10, MIP-1α, MCP-1, MDC, MCP-4, VEGF-C, VEGF-D, Tie-2, Flt-1, PlGF, bFGF, SAA, CRP, VCAM-1, ICAM-1 | K15210G |
| Standard Assays | ||||
| Description | Analytes | Species | Insert | Catalog |
| Number | ||||
| Human (6E10) Aβ38 | Aβ38 | Human | 96-well | K151FSE |
| (6E10 capture, Aβ38 detector) | ||||
| Human (6E10) Aβ40 | Aβ40 | Human | 96-well | K151FTE |
| (6E10 capture, Aβ40 detector) | ||||
| Human (6E10) Aβ42 | Aβ42 | Human | 96-well | K151FUE |
| (6E10 capture, Aβ42 detector) | ||||
| sAPPα 1 | soluble amyloid | Human | 96-well | K151BSE |
| precursor protein α | ||||
| sAPPβ (wt) | soluble amyloid | Human | 96-well | K151BTE |
| precursor protein β | ||||
| sw sAPPβ | Swedish soluble amyloid | Human | 96-well | K151BUE |
| precursor protein β | ||||
| Phospho-Tau (Ser 262) * | Phosphorylated Tau (Ser 262) | Mouse | Contact Customer Service | |
| Phospho-Tau (Thr 231) | Phosphorylated Tau (Thr 231) | Human, Mouse | 96-well | K151DRD |
| Mouse Total Tau | Total Tau | Human, Mouse, Bovine | 96-well | K151DSD |
| β-Secretase | Beta secretase | Human | Contact Customer Service | |
| sAPPα/sAPPβ (Multiplex) 1 | soluble amyloid precursor protein α / | Human | 96-well | K15120E |
| soluble amyloid precursor protein β | ||||
| Phospho (Thr 231) / | Phospho-Tau (Thr 231) / Total Tau | Human, Mouse | 96-well | K15121D |
| Total Tau (Multiplex) | ||||
| α-Synuclein | Alpha-synuclein | Human | 96-well | K151TGD |
| DJ-1/PARK7 | Parkinsons protein 7 | Human | 96-well | K151THD |
| 1 The 6E10, 4G8, 12F4, and Tau antibodies used in MSD assays are supplied by Covance Research Products, Inc. | ||||