FosfomycinDisodiumSaltisanantibioticproducedby StreptomycesfrADIae.ItisaphosphoenolpyruvateanalogthatirreversIBLyinhibitsUDP-GlcNAcenolpyruvyltranferase(MurA),anenzymeinvolvedinbacterialcellwallbiosynthesis.This,inturn,inhibitstheproductionofN-acetylmuramicacid,anessentialelementofthepeptidoglycancellwall.Fosfomycindisodiumsaltconcentratesinthekidneyandbladder,therebyreducingnephrotoxicityandototoxicityofplatinum-containingantitumoragents