产品资料

Tocris/Dynasore/2897/10/10 mg

Description: Non-competitive dynamin inhibitor

Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.

Technical Data

M. Wt	322.32
Formula	C₁₈H₁₄N₂O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	304448-55-3
PubChem ID	5717066
InChI Key	NRQJUIHYFNUXFT-ZHACJKMWSA-N
Smiles	O=C(N/N=C/C3=CC(O)=C(O)C=C3)C2=CC1=CC=CC=C1C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.23	100
	ethanol	1.61	5

Preparing Stock Solutions

The following data is based on the product molecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.1 mL	15.51 mL	31.03 mL
5 mM	0.62 mL	3.1 mL	6.21 mL
10 mM	0.31 mL	1.55 mL	3.1 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Thompson and McNiven (2006) Discovery of a new 'dynasore'. Nat.Chem.Biol. 2 355 PMID: 16783339

Macia et al (2006) Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell 10 839 PMID:

Newton et al (2006) Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA 103 17955 PMID:

Keywords: Dynasore, supplier, Non-competitive, dynamin, 1, 2, mitochondrial, Drp1, inhibitors, inhibits, Mitosis, GTPases, GTPase, Mitosis, GTPase, Tocris Bioscience

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