产品资料

Tocris/IEM 1925 dihydrobromide/4198/10/10 mg

Description: Voltage- and use-dependent open-channel antagonist of AMPA receptors

Chemical Name: N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking receptors more potently than GluR2-containing receptors (K_D for GluR2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 (Cat. No. 4199) due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Technical Data

M. Wt	422.24
Formula	C₁₇H₂₈N₂.2HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	258282-23-4
PubChem ID	44561101
InChI Key	ZCYUSVRXEKAQSL-UHFFFAOYSA-N
Smiles	NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.11	50
	water	42.22	100

Preparing Stock Solutions

The following data is based on the product molecular weight 422.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.68 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232

Kopach et al (2016) Inhibition of spinal Ca²⁺-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front.Cell Neurosci. 10 PMID: 26973464

Keywords: IEM 1925 dihydrobromide, supplier, IEM1925, 2HBr, AMPAR, antagonist, blocks, AMPA, receptor, voltage-dependent, channel, blocker, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience

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