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SelectiveOX2receptorantagonist(pIC50=7.4forchimericOX2receptors;pKBvaluesare5.9and8.5forOX1andOX2receptorsrespectively).Showsnosignificantactivityinapanelofover50otherneurotransmittersandneuropeptidereceptors.AchieveshighlevelofOX2receptoroccupancyintheratbrain;exhibitssleep-promotingeffectsinrats.
JNJ10397049isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 484.18 |
| Formula | C19H20Br2N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 708275-58-5 |
| PubChemID | 9869934 |
| InChIKey | RBKIJGLHFFQHBE-IRXDYDNUSA-N |
| Smiles | O=C(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)NC1=C(Br)C=C(Br)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solubility | Solubleto100mMinDMSOandto100mMinethanol |
Thefollowingdataisbasedontheproductmolecularweight484.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.07mL | 10.33mL | 20.65mL |
| 5mM | 0.41mL | 2.07mL | 4.13mL |
| 10mM | 0.21mL | 1.03mL | 2.07mL |
| 50mM | 0.04mL | 0.21mL | 0.41mL |
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