产品资料

Tocris/Penitrem A/4617/1/1 mg

Description:PotentandselectiveBK_Ca(K_Ca1.1)channelblocker

ChemicalName:2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveblockerofBK_Ca(K_Ca1.1)channels(IC₅₀valuesare6.4and64.4nMforBK_Cachannelscontainingαsubunitsonly,andthosecontainingαandβ1respectively).DisplaysnoeffectonnativedelayedrectifierK⁺andK_ATPcurrents,orclonedK_V1.5channels.BlocksBK_Cachannelsinbothinside-outandcell-attachedpatches.Showntoenhancesmoothmusclecontractioninvitroandincreasetotalperipheralresistanceinvivo.

TechnicalData

M.Wt	634.2
Formula	C₃₇H₄₄ClNO₆
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	12627-35-9
PubChemID	6610243
InChIKey	JDUWHZOLEDOQSR-JKPSMKLGSA-N
Smiles	O[C@H]9[C@@H]([C@](C)=C)O[C@@]([C@@]%108[C@@H]9O%10)([H])CC[C@]([C@@]8(O)CC7)(C)[C@@]([C@]7([H])[C@@H]4OC(C)(C)[C@]([H])5C6)(C)C3=C4C1=C(N3)C=C(Cl)C2=C1[C@@]5(O)[C@@]6([H])C(C2)=C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	6.34	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight634.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.58mL	7.88mL	15.77mL
5mM	0.32mL	1.58mL	3.15mL
10mM	0.16mL	0.79mL	1.58mL
50mM	0.03mL	0.16mL	0.32mL

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Tocris/Penitrem A/4617/1/1 mg

BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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