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Adipogen/PI1840 [Proteasome Inhibitor]/AGCR13675M005/5 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/PI1840 [Proteasome Inhibitor]/AGCR13675M005/5 mg
MoreInformation
ProductDetails
SynonymsN-(1-Methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxADIazol-5-yl]methyl]-acetamide
ProductTypeChemical
Properties
FormulaC22H26N4O3
MW394.5
CAS1401223-22-0
PurityChemicals≥98%
AppearanceWhitesolid.
SolubilitySolubleinDMSO(30mg/ml)orethanol(20mg/ml).Poorlysolubleinaqueoussolutions.
OtherProductDataNote:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice.Stocksolutionsarestableforatleast1monthwhenstoredat-20°C.
InChiKeyZVVXAODXPVWGMF-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceKeepcoolanddry.
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • Highlypotent,selectiveandrapidlyreversIBLenon-covalentproteasomeinhibitor.
  • Targetsthechymotrypsin-likeβ5-subunitoftheconstitutive20Sproteasome(IC50=27nM),withminimalcross-reactivityonthetrypsin-like(β2)andcaspase-like/postglutamyl-peptide-hydrolysis-like(β1)proteolyticactivity(IC50=>100μM,forboth).Exhibitedover100-foldselectivityfortheconstitutive20Sproteasomeovertheimmunoproteasome.
  • Anticancercompound.
  • Invitro,inducestheaccumulationofproteasomesubstratesp27,Bax,andIκB-α,inhibitssurvivalpathwaysandviabilityandinducesapoptosisinintactcancercells.
  • ShowntoinhibittumorgrowthinmiceofMDA-MB-231breasttumors.
ProductReferences
  1. Oxadiazole-isopropylamidesaspotentandnoncovalentproteasomeinhibitors:S.Ozcan,etal.;J.Med.Chem.56,3783(2013)
  2. DiscoveryofPI-1840,anovelnoncovalentandrapidlyreversibleproteasomeinhibitorwithanti-tumoractivity:A.Kazi,etal.;J.Biol.Chem.289,11906(2014)

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