MuscarinicToxin7 (#STM-200) isahighlypure,synthetic,andbiologicallyactivepeptidetoxin.
Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.
Everylotistried&testedinarelevantBIOLOGicalassay.
OurBioassay
Theactionoftheneurotransmitteracetylcholine(Ach)ismediatedthroughtwotypesofreceptors,theionotropicnicotinicreceptorsandthemetabotropicmuscarinicreceptors.ThemuscarinicreceptorsbelongtothesuperfamilyofG-proteincoupledreceptors.Fivesubtypesofmuscarinicreceptorshavebeencloned:m1-m51,2.
Themuscarinicreceptorsarewidelydistributedthroughoutthebody,butarepredominantlyexpressedwithintheparasympatheticnervoussystemandexertbothexcitatoryandinhibitorycontrolovercentralandperipheraltissues1,2.
Muscarinicreceptorsparticipateinanumberofphysiologicalfunctionssuchasregulationofheartrate,musclecontraction,cognition,sensoryprocessingandmotorcontrol1.Theyalsoparticipateinlearningandmemoryprocessing3,4.
MuscarinicToxin7isa65aminoacidpeptidetoxinisolatedfromthe Dendroaspisangusticeps (Easterngreenmamba)5.ItwasfirstfoundtoinhibitM1muscarinicreceptorsstablytransfectedinCHOcellsatverylowconcentrations(1-30nM)6 andactsasanon-competitiveantagonistbybindingtoanallostericsite6.
MuscarinicToxin7bindingstudiesusingaM1andM3chimerademonstratedthatthehighaffinityofMuscarinicToxin7towardsM1receptorisduetoonlythreeresidueslocatedinthe2nd and3rd extracellularloopsofthereceptor7.
MuscarinicToxin7 (#STM-200) isahighlypure,synthetic,andbiologicallyactivepeptidetoxin.
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