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Discovery Antibodies/Muscarinic Toxin 7/1 mg/STM-200-1 mg

Cat#:STM-200
AlternativeNameMuscarinictoxin-7,MT7,muscarinicm1-toxin,m1-toxin1
  • LyophilizedPowder
  • BioassayTested
    • OriginSyntheticpeptide
    MW:7472Da.
    Purity:>98%(HPLC)
    Effectiveconcentration1-100nM.
    SequenceLTCVKSNSIWFPTSEDCPDGQNLCFKRWQYISPRMYDFTRGCAATCPKAEYRDVINCCGTDKCNK.
    ModificationsDisulfidebondsbetweenCys3-Cys24,Cys17-Cys42,Cys46-Cys57,Cys58-Cys63.
      • Muscarinic Toxin 7
    MolecularformulaC322H484N90O98S9.
    CASNo.:135541-77-4.
    ActivityUncompetitiveantagoNISTofM1AChR1.
      • Olianas,M.C. etal. (2000)Br.J.Pharmacol. 131, 447.
    AccessionnumberQ8QGR0.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    SolubilityAnyotheraqueousbuffer,pH>8.Centrifugeallproductpreparationsbeforeuse(10000xg5min).
    StorageofsolutionsUptotwoweeksat4ֲ°Corthreemonthsat-20ֲ°C.
      • Muscarinic Toxin 7
        AlomoneLabsMuscarinicToxin7inhibitsCarbachol-evoked[Ca2+]inincreaseinM1R-expressingC6cells.
        CellswereloadedwithFluo-3AMandpre-incubatedfor20minwithcontrolorwith25nMand100nMMuscarinicToxin7(#STM-200),asindicated,andstimulatedwith100µMCarbachol(arrow).ChangesinintracellularCa2+weredetectedaschangesinFluo-3emissionfollowingstimulation.
    References-Scientificbackground
    • 1.Felder,C.C. etal.(2000) J.Med.Chem. 43,4333.
    • 2.Forsythe,S.M. etal.(2002) Am.J.Respir.Cell.Mol.Biol. 26,298.
    • 3.Ferreira,A.R. etal.(2003) Pharmacol.Biochem.Behav. 74,411.
    • 4.VanderZee,E.A. etal.(1999) Prog.Neurol. 58,409.
    • 5.Adem,A.andKarlsson,E.(1997)LifeSci. 60, 1069.
    • 6.Olianas,M.C. etal. (2000)Br.J.Pharmacol. 131, 447.
    • 7.Kukkonen,A. etal. (2004)J.Biol.Chem. 279, 50923.

      • Theactionoftheneurotransmitteracetylcholine(Ach)ismediatedthroughtwotypesofreceptors,theionotropicnicotinicreceptorsandthemetabotropicmuscarinicreceptors.ThemuscarinicreceptorsbelongtothesuperfamilyofG-proteincoupledreceptors.Fivesubtypesofmuscarinicreceptorshavebeencloned:m1-m51,2.

        Themuscarinicreceptorsarewidelydistributedthroughoutthebody,butarepredominantlyexpressedwithintheparasympatheticnervoussystemandexertbothexcitatoryandinhibitorycontrolovercentralandperipheraltissues1,2.

        Muscarinicreceptorsparticipateinanumberofphysiologicalfunctionssuchasregulationofheartrate,musclecontraction,cognition,sensoryprocessingandmotorcontrol1.Theyalsoparticipateinlearningandmemoryprocessing3,4.

        MuscarinicToxin7isa65aminoacidpeptidetoxinisolatedfromthe Dendroaspisangusticeps (Easterngreenmamba)5.ItwasfirstfoundtoinhibitM1muscarinicreceptorsstablytransfectedinCHOcellsatverylowconcentrations(1-30nM)6 andactsasanon-competitiveantagonistbybindingtoanallostericsite6.

        MuscarinicToxin7bindingstudiesusingaM1andM3chimerademonstratedthatthehighaffinityofMuscarinicToxin7towardsM1receptorisduetoonlythreeresidueslocatedinthe2nd and3rd extracellularloopsofthereceptor7.

    TargetM1muscarinicreceptor
    NetPeptideContent:100%
    LyophilizedPowder
    receivea50µgfreetrialsample!
    Lastupdate:26/09/2019

    MuscarinicToxin7 (#STM-200) isahighlypure,synthetic,andbiologicallyactivepeptidetoxin.

    Forresearchpurposesonly,notforhumanuse
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