LC Labs/B1408 Bortezomib, Free Base, >99%/B1408/50 mg

• Morethan1,000labsworldwidehavepurchasedBortezomibfromLCLabs(eitherdirectlyfromusorfromourmanydistributors,manyofwhomresellundertheirownlabels).
• Potent(Ki,0.6nM),specificandreversIBLeproteasomeinhibitor;nosignificantinhibitoryactivityagainstotherenzymesorreceptors.Bouchard,PR.,etal."NonclinicalDiscoveryandDevelopmentofBortezomib(PS-341,Velcade®),aProteasomeInhibitorfortheTreatmentofCancer."55thAnnualMeetingoftheAmericanCollegeofVeterinaryPathologists(ACVP)&39thAnnualMeetingoftheAmericanSocietyofClinicalPathology(ASVCP),ACVPandASVCP(Eds.)(2004).
• InastudywiththeNationalCancerInstitutespanelof60humancelllines,bortezomibshowedameanIC50of7nMastestedbySRBanalysis.Adams,J.,etal."Proteasomeinhibitors:anovelclassofpotentandeffectiveantitumoragents."CancerRes.59:2615-2622(1999).
• Bortezomibisactiveinpreclinicalmodelsofhumanprostatecancer,whileitseffectsonapoptosisversusangiogenesisarecelltypedependent.BortezomibcausedcomparablegrowthsuppressioninLNCaP-Pro5andPC3M-Pro4cellswithanIC90of10nM.Williams,S.,etal."Differentialeffectsoftheproteasomeinhibitorbortezomibonapoptosisandangiogenesisinhumanprostatetumorxenografts."Mol.CancerTher.2:835-843(2003).
• BortezomibinhibitscellproliferationofH460cells(Humannon-smallcelllungcancercelllines)withanIC50of0.1µM.Ling,Y.,etal."MechanismsofProteasomeInhibitorPS-341-inducedG2-M-PhaseArrestandApoptosisinHumanNon-SmallCellLungCancerCellLines."Clin.CancerRes.9:1145-1154(2003).
• BortezomibistheactiveingredientinthedrugsoldunderthetradenameVelcade®.Thisdrughasbeenapprovedinatleastonecountrytotreatmultiplemyeloma.NOTE:ThebortezomibsoldbyLCLaboratoriesisNOTVelcade®,andisNOTforhumanuse.
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,medical,veterinary,food,orhouseholduse.
• ThisproductisofferedforR&Duseinaccordancewith(i)35USC271(e)+A13(1)intheU.S.;(ii)Section69.1ofJapanesePatentLawinJapan;(iii)Section11,No.2oftheGermanPatentActof1981inGermany;(iv)Section60,Paragraph5boftheU.K.PatentsActof1977intheU.K.;(v)Sections55.2(1)and55.2(6)andothercommonlawexemptionsofCanADIanpatentlaw;(vi)Section68BofthePatentsActof1953inNewZealandtogetherwiththeamendmentofsamebytheStatutesAmendmentBillof2002;(vii)suchrelatedlegislationand/orcaselawasmaybeorbecomeapplicableintheaforementionedcountries;and(viii)suchsimilarlawsandrulesasmayapplyinvariousothercountries.
• Notavailableinsomecountries;notavailabletosomeinstitutions;notavailableforsomeuses.

RelatedTerms:

[Norvelzo][Velcade]
M.W.384.24
C19H25BN4O4
[179324-69-7]
M.I.14:1351

Storage

Storeatorbelow-20ºC

Solubility

SolubleinDMSOat200mg/mL;solubleinethanolat200mg/mL;verypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout5-10µM;buffers,serum,orotheradditivesmayincreaseordecreasetheaqueoussolubility

Disposal

A