NVP-BGJ398isaninhibitorofFGFRthatexhibitsanticancerchemotherapeuticandantirachiticactivities.NVP-BGJ398inhibitscellviabilityincoloncancercellsandpreventsprogressionandtumorformationinanimalmodelsofmalignantrhabdoidtumors.Inendometrialcancercells,NVP-BGJ398inducescellcyclearrestandinhibitsgrowth;invivo,italsoinhibitstumorgrowth.NVP-BGJ398inhibitsaberrantFGFRsignalinginanimalmodelsofricketsdisease,normalizingbonegrowthandmineralization.
| CasNo. | 872511-34-7 |
|---|---|
| Purity | ≥98% |
| Formula | C26H31Cl2N7O3 |
| FormulaWt. | 560.48 |
| IUPACName | 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea |
| Synonym | BGJ398,BGJ-398 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | N8662InfoSheetPDF |
|---|
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