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Hello Bio/VU 0361737/HB0638/50mg

Productoverview

  • Name
    VU0361737
  • Shortdescription
    mGlu4positiveallostericmodulator
  • Biologicaldescription
    mGlu4receptorpositiveallostericmodulator(EC50=0.24µM).DisplayslittleactivityatmGlu5andmGlu8receptorsandnoactivityatmGlu1,2,3,6and7receptors.Blood-brainbarrierpermeable.
  • Biologicalaction
    PAM
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
  • MolecularWeight
    262.69
  • Chemicalstructure
    VU 0361737 [1161205-04-4]
  • MolecularFormula
    C13H11ClN2O2
  • CASNumber
    1161205-04-4

StoringandUsingYourProduct

  • Storageinstructions
    roomtemperature
  • Solubilityoverview
    solubleinDMSO(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforVU0361737

  • RadiosynthesisofN-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide([(11)C]ML128)asaPETradiotracerformetabotropicglutamatereceptorsubtype4(mGlu4).

    KilKEetal(2013)BioorgMedChem21(19):5955-62.
    PubMedID:23978356

  • Discovery,synthesis,andstructure-activityrelationshipdevelopmentofaseriesofN-(4-acetamido)phenylpicolinamidesaspositiveallostericmodulatorsofmetabotropicglutamatereceptor4(mGlu(4))withCNSexposureinrats.

    EngersDWetal(2011)JMedChem54(4):1106-10.
    PubMedID:21247167

  • Synthesisandevaluationofaseriesofheterobiarylamidesthatarecentrallypenetrantmetabotropicglutamatereceptor4(mGluR4)positiveallostericmodulators(PAMs).

    EngersDWetal(2009)JMedChem52(14):4115-8.
    PubMedID:19469556

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