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Adipogen/6ECDCA/AGCR13560M025/25 mg
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ProductDetails
Synonyms6α-Ethyl-chenodeoxycholicacid;6-α-ECDC;Obeticholicacid;INT-747;OCA
ProductTypeChemical
Properties
FormulaC26H44O4
MW420.6
CAS459789-99-2
PurityChemicals≥95%(NMR)
AppearanceWhitesolid.
SolubilitySolubleinethanol,methanol,orDMSO.Slightlysolubleinwater,dichloromethaneandacetone.
IdentityIdentitydeterminedby1H-NMR.
InChiKeyZXERDUOLZKYMJM-AMGBFIHRSA-N
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • PotentandselectiveFXRagonist(EC50=99nM)[1].
  • InducesSHPinHSCstosuppressTIMP-1expression[2].
  • Apoptosisinducer[2]. 
  • Protectsagainstliverfibrosisdevelopmentinrat invivo [2].
  • Displaysanticholereticactivityinratinvivo[3].
  • Promotespreadipocytedifferentiation[4]. 
  • Regulatesadipogenesisandinsulinsignaling invivo[4].
  • Inhibitsvascularsmoothmusclecellinflammationandmigration[5].
ProductReferences
  1. 6r-Ethyl-chenodeoxycholicacid(6-ECDCA),apotentandselectiveFXRagonistendowedwithanticholestaticactivity:R.Pellicciari,etal.;J.Med.Chem.45,3569(2002)
  2. AfarnesoidXreceptor-smallheterodimerpartnerregulatorycascademodulatestissuemetalloproteinaseinhibitor-1andmatrixmetalloproteaseexpressioninhepaticstellatecellsandpromotesresolutionofliverfibrosis:S.Fiorucci,etal.;J.Pharmacol.Exp.Ther. 314,584(2005)
  3. Protectiveeffectsof6-ethylchenodeoxycholicacid,afarnesoidXreceptorligand,inestrogen-inducedcholestasis:S.Fiorucci,etal.;J.Pharmacol.Exp.Ther.313,604(2005)
  4. ThefarnesoidXreceptorpromotesadipocytedifferentiationandregulatesadiposecellfunctioninvivo:G.Rizzo,etal.;Mol.Pharmacol.70,1164(2006)
  5. FarnesoidXreceptorligandsinhibitvascularsmoothmusclecellinflammationandmigration:Y.T.Li,etal.;Arterioscler.Thromb.Vasc.Biol.27,2606(2007)
  6. ComputationaldiscoveryandexperimentalverificationoffarnesoidXreceptoragonistauraptenetoprotectagainstcholestaticliverinjury:X.Gao,etal.;Biochem.Pharmacol.aheadofprint(2017)

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