OSI-906inhibitsIGF-1RandInsR,displayinganticancerchemotherapeuticactivity;itiscurrentlyinclinicaltrialsasapotentialtreatmentforcolorectalcancer.Inanimalmodelsofovariancancer,OSI-906inhibitstumordevelopmentandgrowth.Thiscompoundalsodecreasestumorgrowthinanimalmodelsoffibroblasttumors.OSI-906inhibitscellproliferationincolorectalcancer,breastcancer,pancreaticcancer,andnon-smallcelllungcancer(NSCLC)cells.
| CasNo. | 867160-71-2 |
|---|---|
| Purity | ≥98% |
| Formula | C26H23N5O |
| FormulaWt. | 421.49 |
| IUPACName | cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol |
| Synonym | OSI906,Linsitinib |
| Appearance | Paleyellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | O7333InfoSheetPDF |
|---|
BendellJC,JonesSF,HartL,etal.AphaseIbstudyoflinsitinib(OSI-906),adualinhibitorofIGF-1RandIRtyrosinekinase,incombinationwitheverolimusastreatmentforpatientswithrefractorymetastaticcolorectalcancer.InvestNewDrugs.2015Feb;33(1):187-93.PMID:25335932.
RaoW,LiH,SongF,etal.OVA66increasescellgrowth,invasionandsurvivalviaregulationofIGF-1R-MAPKsignalinginhumancancercells.Carcinogenesis.2014Jul;35(7):1573-81.PMID:24667688.
MulvihillMJ,CookeA,Rosenfeld-FranklinM,etal.DiscoveryofOSI-906:aselectiveandorallyefficaciousdualinhibitoroftheIGF-1receptorandinsulinreceptor.FutureMedChem.2009Sep;1(6):1153-71.PMID:21425998.