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Hello Bio/Torin 1/HB2253/50mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Hello Bio/Torin 1/HB2253/50mg

Productoverview

  • Name
    Torin1
  • Shortdescription
    Potent,selectivemTORinhibitor
  • Biologicaldescription
    Potent,selectiveandATP-competitivemTORinhibitor(IC50valesare2and10nMatmTORC1andmTORC2respectively).Exhibits1000-foldselecticityformTORoverPI3Kand~100-foldselectivitywhencomparedto450otherproteinkinases.Impairscellgrowthandproliferationtoagreaterdegreethanrapamycin.
  • Biologicalaction
    Inhibitor
  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
  • MolecularWeight
    607.62
  • MolecularFormula
    C35H28F3N5O2
  • CASNumber
    1222998-36-8

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforTorin1

  • Discoveryof1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-oneasahighlypotent,selectivemammaliantargetofrapamycin(mTOR)inhibitorforthetreatmentofcancer.

    Liuetal(2010)JMedCHem53(19):7146-55
    PubMedID:20860370

  • AnATP-competitivemammaliantargetofrapamycininhibitorrevealsrapamycin-resistantfunctionsofmTORC1.

    Thoreenetal(2009)JBiolChem284(12):8023-32
    PubMedID:19150980

  • Selectivetargetingofhumancoloncancerstem-likecellsbythemTORinhibitorTorin-1.

    FrancipaneandLagasse(2013)Oncotarget4(11):1948-62
    PubMedID:24185040

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